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Opinion|Videos|October 14, 2024

COSMOS-CRC-01: Clinicopathologic Correlation of ctDNA With RFS

Author(s)Yoshiaki Nakamura, MD, PhD

Yoshiaki Nakamura, MD, PhD, discusses how the COSMOS-CRC-01 study demonstrated statistically significant recurrence-free intervals across various postoperative and adjuvant chemotherapy time points, highlighting the prognostic value of serial, tissue-free ctDNA assays for real-time detection of MRD vs single postchemotherapy assessments.

Episodes in this series

EP. 1 Risk of Recurrent Colorectal Cancer Following Definitive Therapy

EP. 1 Risk of Recurrent Colorectal Cancer Following Definitive Therapy

EP. 2 COSMOS-CRC-01: Study Design and Methodology

EP. 2 COSMOS-CRC-01: Study Design and Methodology

EP. 3 COSMOS-CRC-01: Clinicopathologic Correlation of ctDNA With RFS

EP. 3 COSMOS-CRC-01: Clinicopathologic Correlation of ctDNA With RFS

EP. 4 COSMOS-CRC-01: Sensitivity and Specificity of a Serial, Cell-Free DNA Epigenomic Platform in Detecting MRD in Real Time

EP. 4 COSMOS-CRC-01: Sensitivity and Specificity of a Serial, Cell-Free DNA Epigenomic Platform in Detecting MRD in Real Time

EP. 5 Concluding Remarks for the Current Use of ctDNA Testing for Treatment Decisions in stage II-III CRC

EP. 5 Concluding Remarks for the Current Use of ctDNA Testing for Treatment Decisions in stage II-III CRC

1. Please summarize the statistically significant recurrence-free intervals across the postoperative, post-ACT, and paired pre- and post-ACT analyses in the COSMOS-CRC-01 study.

2. Please address the prognostic value of serial, tissue-free, epigenomic ctDNA assays in detecting MRD in real time vs a single postchemotherapy time point.

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