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Opinion|Videos|March 20, 2026

Dosing Strategies and Real World Implementation of Maintenance Therapy

Author(s)Stephen V. Liu, MD, Georgetown University, Ticiana A. Leal, MD

Relapsed small cell lung cancer care evolves as tarlatamab boosts survival but needs CRS/ICANS monitoring, while lurbinectedin offers simpler dosing.

Episodes in this series

EP. 1 First Line Maintenance in Extensive Stage Small Cell Lung Cancer

EP. 1 First Line Maintenance in Extensive Stage Small Cell Lung Cancer

EP. 2 Reviewing the IMforte Phase 3 Data in Extensive Stage Small Cell Lung Cancer

EP. 2 Reviewing the IMforte Phase 3 Data in Extensive Stage Small Cell Lung Cancer

EP. 3 Safety Profile of Lurbinectedin and Patient Selection for Maintenance Therapy

EP. 4 Management of Brain Metastases in Extensive Stage Small Cell Lung Cancer

EP. 4 Management of Brain Metastases in Extensive Stage Small Cell Lung Cancer

EP. 5 Applying IMforte Data to a Clinical Scenario

EP. 5 Applying IMforte Data to a Clinical Scenario

EP. 6 Dosing Strategies and Real World Implementation of Maintenance Therapy

EP. 6 Dosing Strategies and Real World Implementation of Maintenance Therapy

EP. 7 Future of Optimal Maintenance Therapy in ES-SCLC

EP. 7 Future of Optimal Maintenance Therapy in ES-SCLC

This segment addresses the practical implementation of maintenance therapy in extensive stage small cell lung cancer. Topics include dosing intervals for lurbinectedin, laboratory monitoring schedules, management of cumulative toxicity, and coordination with ongoing immunotherapy. Operational considerations such as infusion logistics, clinic workflow, and patient access are incorporated into the discussion. The episode also reviews how emerging therapeutic agents with distinct mechanisms of action may influence sequencing decisions in the maintenance setting. By examining both clinical and operational factors, the discussion outlines how maintenance therapy can be integrated consistently and safely into routine oncology practice. Emphasis is placed on sustaining disease control while minimizing treatment related burden.

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