Dr. Baas on Immunotherapy in Mesothelioma Subpopulations

Video

Paul Baas, MD, PhD, discusses the benefits of immunotherapy in subpopulations of patients with mesothelioma. 

Paul Baas, MD, PhD, chief, Department of Thoracic Oncology, Netherlands Cancer Institute, discusses the benefits of immunotherapy in subpopulations of patients with mesothelioma. 

The phase 3 CheckMate743 trial (NCT02899299) investigated frontline nivolumab (Opdivo) plus ipilimumab (Yervoy) vs chemotherapy in patients with unresectable pleural mesothelioma. In an updated 3-year analysis of these data, the median overall survival (OS) in patients with non-epithelioid histology who received the immunotherapy combination was 18.1 months vs 8.8 months in the chemotherapy arm.

Patients with non-epithelioid mesothelioma have historically demonstrated unfavorable OS rates, Baas says. Although OS improved slightly with the introduction of chemotherapy in this population, immunotherapy, as shown in CheckMate743, improved OS by 9.3 months, Baas explains. 

Immunotherapy is beneficial for patients with non-epithelioid mesothelioma and should be offered to patients who have no contraindications, Baas highlights. Although this OS benefit was slightly less pronounced in the epithelioid population, it was still favorable in this subgroup, Baas says. Overall, the patients studied in this trial showed interesting and encouraging survival rates, Baas concludes. 

Related Videos
Neal Shore, MD, FACS, discusses current and ongoing research with radioligand therapy in patients with nonmetastatic castration-sensitive prostate cancer.
Jane L. Meisel, MD
Kari Wisinski, MD, Endowed Professor of Hematology and Oncology, chief, Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, University of Wisconsin (UW) School of Medicine and Public Health; associate director, Clinical Research, co-lead, Breast Cancer Disease Oriented Team, UW Carbone Cancer Center
Susan C. Modesitt, MD, FACOG, FACS, professor, Department of Gynecology and Obstetrics, director, Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, Emory University School of Medicine
Nikhil A. Gopal, MD
Hans C. Lee, MD
Manish A. Shah, MD
Jobelle Baldonado, MD
Alexey Danilov, MD, PhD,