Dr. Burris on the Potential for Novel Checkpoint Inhibitor Combinations in Oncology

Video

In Partnership With:

Howard A. “Skip” Burris, III, MD, FASCO, FACP, discusses the potential of novel combination strategies with checkpoint inhibitors in oncology.

Howard A. “Skip” Burris, III, MD, FASCO, FACP, chief medical officer and president of Clinical Operations at Sarah Cannon Research Institute, and a 2014 Giant of Cancer Care® in Drug Development, discusses the potential of novel combination strategies with checkpoint inhibitors in oncology.

Ongoing trials are evaluating PD-L1 inhibitors in combination with novel therapies, such as TIGIT- and LAG-3–directed antibodies, says Burris. Early data have shown improved activity with combination regimens compared with single-agent checkpoint inhibitors. Additionally, these novel therapies appear to improve activity versus single-agent treatment in patients who have received prior checkpoint inhibitors, Burris explains.

Moreover, these benefits have been observed across a wide section of oncology, including lung cancer, colon cancer, and melanoma, says Burris. As such, the potentially diverse application of these therapies is an exciting research effort to keep an eye on in 2021.

Related Videos
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,
Guenther Koehne, MD, PhD
Alessandro Villa, DDS, PhD, MPH
Joseph Mikhael, MD
Michael Richardson, MD
Minesh Mehta, MD
Ruben Olivares, MD
Phillip J. Koo, MD