Dr. Dandoy on Overcoming Challenges with TA-TMA

Christopher E. Dandoy, MD, MSc, a professor at Cincinnati Children’s Hospital, shares advice for how to overcome the challenges in managing transplanted-associated thrombotic microangiopathy (TA-TMA). The primary challenges are diagnosing and identifying TA-TMA in patients.

Dandoy recommends screening for TA-TMA to overcome this issue. Institutions should obtain complete blood counts for the first month in patients following transplant, as well as renal profiles to look at kidney injury on a daily basis. In addition, physicians should look at lactate dehydrogenase, urine, and for signs of schistocytes in the blood. Dandoy concludes they should also monitor blood pressure closely.