Video

Dr. Elemento on Utilizing Circulating Tumor Cells to Assess Treatment Resistance in mCRPC

Olivier Elemento, PhD, discusses utilizing circulating tumor cells to assess treatment resistance in metastatic castration-resistant prostate cancer.

Olivier Elemento, PhD, professor, Physiology and Biophysics, Walter B. Wriston Research Scholar, professor, Computational Genomics, Computational Biomedicine, associate director, the Institute for Computational Biomedicine, Weill Cornell Medicine, Physiology and Biophysics, director, the Englander Institute, Precision Medicine Associate, director, the Institute for Computational Biomedicine, discusses utilizing circulating tumor cells (CTCs) to assess treatment resistance in metastatic castration-resistant prostate cancer (mCRPC).

The detection of an inflammatory response signature in CTCs was found to be associated with acquired antiandrogen resistance, Elemento says. Moreover, examining the transcriptome of immune cells in the blood showed that an enrichment of gene signatures, such as the inflammasome gene signature, served as another indicator of progression, Elemento explains

The detection and change of these signatures at various points of disease can help predict progression, making it important to evaluate these signatures at diagnosis, Elemento continues. This research could help indicate if a change in expression of gene signatures are correlated with progression, which could assist in preventing progression in the future, Elemento continues. Leveraging CTCs at baseline could serve as an earlier indicator of which patients are more likely to progress, and these data could drive treatment decisions in patients to potentially prevent progression, Elemento concludes.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity