Dr. Halmos on Second-Line Treatment in Metastatic Squamous NSCLC | OncLive

Dr. Halmos on Second-Line Treatment in Metastatic Squamous NSCLC

November 2, 2018

Balazs Halmos, MD, MS, director of thoracic oncology and director of clinical cancer genomics, Montefiore Medical Center, discusses second-line treatment for patients with metastatic squamous non–small cell lung cancer (NSCLC).

Balazs Halmos, MD, MS, director of thoracic oncology and director of clinical cancer genomics, Montefiore Medical Center, discusses second-line treatment for patients with metastatic squamous non—small cell lung cancer (NSCLC).

If a patient progresses on chemoimmunotherapy in the first-line setting, their options are limited in the second-line, explains Halmos. As it stands, the standard of care for the management of metastatic nonsquamous NSCLC, metastatic squamous cell lung cancer, and extensive-stage small cell lung cancer should be a combination of chemotherapy and immunotherapy, says Halmos.

While second-line chemotherapy does benefit patients, benefits that can be enhanced in the right subsets with the addition of ramucirumab (Cyramza), physicians must work harder to achieve more than what second-line chemotherapy can do, says Halmos. Physicians need to understand the mechanisms of resistance to immunotherapy and focus on individualized strategies in terms of chimeric antigen receptor T cells and other classes of agents. There is a lot of research that physicians still need to do, though a lot has been accomplished, Halmos concludes.


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