Video

Dr. Hardesty on Bevacizumab/PARP Inhibitor Combination in Ovarian Cancer

Melissa Hardesty, MD, gynecologic oncologist, Alaska Women’s Cancer Center, discusses the safety and efficacy of the bevacizumab/PARP inhibitor combination in ovarian cancer.

Melissa Hardesty, MD, gynecologic oncologist, Alaska Women’s Cancer Center, discusses the safety and efficacy of the bevacizumab (Avastin)/PARP inhibitor combination in ovarian cancer. She presented phase II findings from the OVARIO trial at the 2018 ASCO Annual Meeting.

Bevacizumab and niraparib (Zejula) is an aggressive and effective combination, particularly in upfront maintenance, and Hardesty says this won’t become the standard of care for all patients. There is a small fraction of patients who will be cured after frontline maintenance therapy, so physicians don’t want to put patients on 2 additional years of adjuvant therapy if they don’t need it. Hardesty says the best patient population for this combination would be those who have a suspected short disease-free interval. An example of these patients would be those who are diagnosed early on with stage IV disease.

Bevacizumab monotherapy has shown activity in these patient populations.

Related Videos
Leah Backhus, MD, MPH, FACS, professor, University Medical Line, Cardiothoracic Surgery, co-director, Thoracic Surgery Clinical Research Program, associate program director, Thoracic Track, CT Surgery Residency Training Program, Thelma and Henry Doelger Professor of Cardiovascular Surgery, Stanford Medicine; chief, Thoracic Surgery, VA Palo Alto
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Medical Oncology, director, Center for Thoracic Cancers, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine
Chirag Shah, MD
Jason A. Mouabbi, MD
Roger Li, MD,
Brian I. Rini, MD, FASCO
Marc-Oliver Grimm, MD
David Samuel Dicapua Siegel, MD
Moritz Fürstenau, MD
Joseph Franses, MD, PhD