Video

Dr. Liu on Phase 2 Study Results of Adavosertib in Recurrent Uterine Serous Carcinoma

Joyce F. Liu, MD, MPH, discusses findings from a phase 2 study with the Wee1 inhibitor adavosertib in patients with recurrent uterine serous carcinoma.

Joyce F. Liu, MD, MPH, assistant professor of medicine, Harvard Medical School, and director of clinical research for gynecologic oncology at Dana-Farber Cancer Institute, discusses findings from a phase 2 study with the Wee1 inhibitor adavosertib in patients with recurrent uterine serous carcinoma.

The study enrolled 35 patients, 34 of which were evaluable for response, says Liu.

In order to be eligible for the study, patients had to have had at least 1 prior platinum-based chemotherapy regimen. Patients in the study had received a median of 3 prior lines of therapy.

Among these 34 patients, the overall response rate was 29.4% (95% CI, 15.1-47.5), says Liu. Additionally, the median progression-free survival was 6.1 months, and the median duration of response was 9.0 months.

Regarding safety, the adverse effects (AEs) were consistent with previously reported data with adavosertib in this patient population, explains Liu. Common grade 3 or higher AEs included neutropenia, anemia, and fatigue.

Additionally, 2 patients discontinued treatment due to AEs; however, dose modifications and dose adjustments allowed the regimen to be well tolerated by most women, concludes Liu.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity