Dr. Matasar on the Design of the CHRONOS-3 Trial Examining Copanlisib/Rituximab in Indolent NHL

Video

Matthew J. Matasar, MD, discusses the design of the phase 3 CHRONOS-3 trial in indolent non-Hodgkin lymphoma.

Matthew J. Matasar, MD, a medical oncologist and Regional Care Network Medical Site Director at Memorial Sloan Kettering Cancer Center Bergen, discusses the design of the phase 3 CHRONOS-3 trial (NCT02367040) in indolent non-Hodgkin lymphoma (iNHL).

In the globally conducted, randomized CHRONOS-3 trial, patients with iNHL received either copanlisib (Aliqopa) plus rituximab (Rituxan) or rituximab plus placebo, Matasar says. Patients were randomized 2:1, meaning that of every 3 patients who enrolled to the trial, 2 patients would receive the combination regimen, while 1 would receive rituximab plus a placebo. A total of 458 patients were randomized; of these patients, 307 received the copanlisib combination and 151 received rituximab plus placebo, Matasar concludes.

Related Videos
Rahul Banerjee, MD, FACP, assistant professor, Clinical Research Division, Fred Hutchinson Cancer Center; assistant professor, Division of Hematology and Oncology, University of Washington
Julie M. Vose, MD, MBA
Lori A. Leslie, MD
David J. Andorsky, MD
Michael R. Cook, MD
Peter Riedell, MD
Paolo Strati, MD
Stephen M. Ansell, MD, PhD
Jason R. Westin, MD
Loretta J. Nastoupil, MD