Video

Dr. Mesa on Ruxolitinib Vs Fedratinib in Myelofibrosis Treatment

Author(s):

Ruben Mesa, MD, discusses the use of ruxolitinib versus fedratinib in treating patients with myelofibrosis.

Ruben Mesa, MD, the director of the Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, discusses the use of ruxolitinib (Jakafi) versus fedratinib (Inrebic) in treating patients with myelofibrosis.

Ruxolitinib has been the approved frontline therapy of choice for several years. The FDA approval of fedratinib immediately impacts patients who did not have an optimal response to ruxolitinib or those who lost their response and may benefit moving on to a different agent, explains Mesa.

Currently, there are no head-to-head data on fedratinib versus ruxolitinib. Both had positive phase III studies, but the agents have slightly different toxicity profiles that need to be considered. Fedratinib may benefit subsets of patients with significant splenomegaly or more advanced myelofibrosis, according to Mesa. Each agent will find its niche in frontline therapy as time goes on, Mesa concludes.

Related Videos
Yair Lotan, MD, UT Southwestern Medical Center
Alan Tan, MD, Vanderbilt-Ingram Cancer Center
Alex Herrera, MD
Roy S. Herbst, MD, PhD
Sheldon M. Feldman, MD
Laura J. Chambers, DO
Thomas Westbrook, MD
Massimo Cristofanilli, MD, attending physician, NewYork-Presbyterian Hospital; professor, medicine, Weill Cornell Medical College, Cornell University
Fred Saad, CQ, MD, FRCS, FCAHS, director, Prostate Cancer Research, Montreal Cancer Institute, Centre Hospitalier de l’Université de Montréal; full professor, Department of Surgery, Université de Montréal; uro-oncologist, Urology Department, University of Montreal Health Center
Ajay K. Nooka, MD, MPH, FACP