Dr. Raghav on Treatment Considerations With Regorafenib and TAS-102 in CRC

Video

Kanwal Raghav, MBBS, MD, discusses the safety profiles of regorafenib and trifluridine/tipiracil, and selecting between the agents for the treatment of patients with colorectal cancer.

Kanwal Raghav, MBBS, MD, associate professor, Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the safety profiles of regorafenib (Stivarga) and trifluridine/tipiracil (Lonsurf; TAS-102), and selecting between the agents for the treatment of patients with colorectal cancer (CRC).

The safety profiles of regorafenib and TAS-102 are often used to inform selection between the agents, according to Raghav. If a patient has received chemotherapy and is experiencing bone marrow depression, they should not receive treatment with TAS-102 due to the additional bone marrow toxicity associated with the agent, Raghav explains. Furthermore, if a patient has undergone peritoneal surgery and experienced diarrhea on prior lines of treatment, regorafenib would not be a favorable option, Raghav adds.

Patient selection is key, and it is important to base decisions on what the trials have demonstrated, Raghav says. Patients who are selected for regorafenib or TAS-102 should have good performance status to ensure the drugs are effective as possible, Raghav concludes. 

Related Videos
Hetty E. Carraway, MD, MBA, staff associate professor, Department of Medicine, School of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University; member, Immune Oncology Program, Case Comprehensive Cancer Center; vice chair, Strategy and Enterprise Development, Taussig Cancer Institute, Division of Hematologic Oncology and Blood Disorders, Cleveland Clinic
David A. Braun, MD, PhD, assistant professor, medicine (medical oncology), Louis Goodman and Alfred Gilman Yale Scholar, member, Center of Molecular and Cellular Oncology, Yale Cancer Center
Julia Foldi, MD, PhD
Vikram M. Narayan, MD
C. Ola Landgren, MD, PhD
Timothy Yap, MBBS, PhD, FRCP
Muhamed Baljevic, MD, FACP
Kathleen A. Dorritie, MD
David L. Porter, MD, director, Cell Therapy and Transplant, Jodi Fisher Horowitz Professor in Leukemia Care Excellence, Penn Medicine
Muhamed Baljevic, MD