Dr. Sasine on Determining Outlook With CAR T-Cell Therapy in Hematologic Cancers

Video

Joshua P. Sasine, MD, PhD, clinical instructor of medicine, University of California, Los Angeles, discusses how to determine if a patient will have a response to CAR T-cell therapy.

Joshua P. Sasine, MD, PhD, clinical instructor of medicine, University of California, Los Angeles, discusses how to determine if a patient will have a response to CAR T-cell therapy.

Currently, it is difficult to determine who is going to benefit the most from CAR T-cell therapy, according to Sasine. However, researchers are getting closer to that because there are certain cytokine profiles now known, both before and after CAR T cells are given, that are associated with long-term, durable remissions, explains Sasine.

Lymphodepletion can also be a signal to determine response to CAR T cell therapy. This is something that can be modified within a physician's control, whereas other aspects are unmodifiable but can be helpful for predicting response.

Related Videos
Samilia Obeng-Gyasi, MD, MPH
Tycel Phillips, MD
Ajai Chari, MD
Reshma Jagsi, MD, DPhil, Emory University
Nisha A. Mohindra, MD, Northwestern University Feinberg School of Medicine
Katrina S. Pedersen, MD, MS, associate professor, John T. Milliken Department of Medicine, Division of Oncology, Medical Oncology program leader, cofounder, Young Onset Colorectal Cancer Program, Washington University School of Medicine in St. Louis, Siteman Cancer Center
Dan S. Childs, MD, medical oncologist, Mayo Clinic
Neal Shore, MD, FACS, discusses current and ongoing research with radioligand therapy in patients with nonmetastatic castration-sensitive prostate cancer.
Jane L. Meisel, MD