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Dr. Neal Shore, from the Atlantic Urology Clinics, Discusses the Enzalutamide (MDV3100) AFFIRM Trial
Neal D. Shore, MD, Managing Partner, Atlantic Urology Clinics, Director, CPI, Carolina Urologic Research Center, discusses findings from the phase III AFFIRM trial that examined the new oral agent enzalutamide (formally MDV3100) for patients with castration-resistant prostate cancer who have failed a prior docetaxel-based chemotherapy.
The trial randomized 1199 patients in a 2:1 ratio to receive either enzalutamide or placebo. The median overall survival benefit for those receiving enzalutamide was 18.4 months compared to 13.6 months in the placebo arm, representing a 4.8-month increase in median overall survival.