Dr. Smith on the Brachytherapy Breast Cancer Trial

Dr. Benjamin Smith from MD Anderson Cancer Center Discusses the Brachytherapy Breast Cancer Trial

Benjamin D. Smith, MD, Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, discusses a clinical trial that compared whole-breast irradiation (WBI) to accelerated partial breast brachytherapy (APBI-brachy) for women that were diagnosed with incident-invasive breast cancer after lumpectomy.

The study looked at 130 535 Medicare patients age 66 and older that were diagnosed with invasive breast cancer between 2000 and 2007. Compared to WBI the patients receiving APBI-brachy had a much higher incidence of mastectomy within 5 years of treatment, postoperative infections, breast pain, and fat necrosis.

Smith describes the trial as being novel and intriguing because of the unexpected illustration of outcomes demonstrated between the two therapies. A complex trade-off between the two therapies has been revealed and an appreciation of the differences will help clinicians and patients determine the best radiation treatment approach.

>>>Return to the main conference coverage page.

Related Videos
Julia Rotow, MD, clinical director, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute; assistant professor, medicine, Harvard Medical School
Joshua K. Sabari, MD, assistant professor, Department of Medicine, New York University Grossman School of Medicine; director, High Reliability Organization Initiatives, Perlmutter Cancer Center
Alastair Thompson, BSc, MBChB, MD, FRCS
Adam M. Brufsky, MD, PhD, FACP
Sara M. Tolaney, MD, MPH
Leah Backhus, MD, MPH, FACS, professor, University Medical Line, Cardiothoracic Surgery, co-director, Thoracic Surgery Clinical Research Program, associate program director, Thoracic Track, CT Surgery Residency Training Program, Thelma and Henry Doelger Professor of Cardiovascular Surgery, Stanford Medicine; chief, Thoracic Surgery, VA Palo Alto
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Medical Oncology, director, Center for Thoracic Cancers, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine
Chirag Shah, MD
Jason A. Mouabbi, MD
2 KOLs are featured in this program.