Dr. Smith on Ongoing Research in Relapsed/Refractory MCL

Sonali M. Smith, MD, discusses ongoing research in relapsed/refractory mantle cell lymphoma.

Sonali M. Smith, MD, Elwood V. Jensen Professor in Medicine, interim chief, Section of Hematology/Oncology, director, Lymphoma Program, University of Chicago Medicine, discusses ongoing research in relapsed/refractory mantle cell lymphoma (MCL).

Despite the introduction of BTK inhibitors, relapsed/refractory MCL remains incurable and is associated with poor survival, says Smith.

CAR T-cell therapy is an area of active research that appears promising, says Smith. Although the data sets are relatively small, CAR T-cell therapy could offer a different way of treating patients with MCL compared with traditional chemotherapy. The modality could also lead to better disease control, explains Smith.

Additionally, combinations of BCL-2 inhibitors with BTK inhibitors are also being investigated in the relapsed/refractory setting, concludes Smith.

Related Videos
Amandeep Godara, MBBS
Eunice Wang, MD
Yvonne Chao, MD, PhD
Ruth M. O’Regan, MD, professor, chair, Charles Ayrault Dewey Professorship of Medicine, Department of Medicine, the University of Rochester, physician-in-chief, Strong Memorial Hospital, associate director, Education and Mentoring, the Wilmot Cancer Institute at University of Rochester,
Timothy Burns, MD, PhD, associate professor of medicine, associate program director, Research, associate program director, Hematology/Oncology Fellowship Program, Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center
Sapna Patel, BA, MD
Brian Henick, MD
R. Lor Randall, MD, FACS
Edward B. Garon, MD, MS, professor of medicine, Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine, the University of California, Los Angeles (UCLA), UCLA Health
Matthew Brunner, MD, assistant professor, hematologic specialist, medical oncology, and palliative care, Department of Medicine, University of Wisconsin Carbone Cancer Center
Related Content