Video

Dr. Thomas on Potential Biomarkers of Response to Berzosertib/Topotecan in SCLC

Anish Thomas, MD, discusses potential biomarkers of response to the combination of berzosertib plus topotecan in patients with relapsed, platinum-resistant small cell lung cancer.

Anish Thomas, MD, medical oncologist, Lasker clinical research scholar, developmental therapeutics branch, Center for Cancer Research, National Cancer Institute, Mercy Clinic, discusses potential biomarkers of response to the combination of berzosertib plus topotecan in patients with relapsed, platinum-resistant small cell lung cancer (SCLC).

The phase 2 DDRiver SCLC 250 trial (NCT04768296), which assessed the efficacy of berzosertib plus topotecan in this patient population, also examined biomarkers of response to the combination, according to Thomas. However, because the rapid progression of the disease makes it challenging to collect the necessary tumor tissues, biomarkers can often be difficult to assess, Thomas adds.

In the trial, biopsies were done on 20 patients and showed that those with high neuroendocrine differentiation may be more likely to respond to the combination vs those with low differentiation, Thomas explains. Ongoing research with the combination will further evaluate, and hopefully be informed by, biomarkers of response, Thomas concludes.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity