Video

Dr. Wolf on the Design of GEOMETRY mono-1 Trial in METex14-Mutated NSCLC

Jüergen Wolf, MD, discusses the design and rationale of the phase 2 GEOMETRY mono-1 study with capmatinib (Tabrecta) in METex14-mutated or high MET amplified, advanced non–small cell lung cancer.

Jüergen Wolf, MD, medical director of the Center for Integrated Oncology and professor of Interdisciplinary Translational Oncology at the University Hospital of Cologne, discusses the design and rationale of the phase 2 GEOMETRY mono-1 study with capmatinib (Tabrecta) in METex14-mutated or high MET amplified, advanced non–small cell lung cancer (NSCLC).

The GEOMETRY mono-1 study was a global, multicohort trial evaluating capmatinib in patients with METex14-mutated advanced NSCLC who received prior immunotherapy. The trial systematically evaluated patients according to the line of therapy and molecular driver status, says Wolf. Within the 4 different cohorts, 3 had low and medium amplification with up to a copy number of 9, while the fourth cohort included highly amplified patients, with a copy number of ≥10.

Last year, the initial results were reported on patients with METex14 skipping mutations. Results showed that there was efficacy with the agentin pretreated patients with advanced NSCLC who were receiving treatment in the second- or third-line of therapy, says Wolf. Patients experienced an overall response rate of 39.1% and duration of response was 9.72 months. For this cohort, the primary end point was met because a lower boundary of 35% was assumed. Investigators determined that the trial would be successful if in the pretreatment setting, at least 35% of the patients showed a response. These datacompare favorably with that seen with standard relapsed therapies, concludes Wolf.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity