Dr. Yee on Trials Evaluating Treatment in Lenalidomide-Refractory Multiple Myeloma

Andrew Yee, MD, discusses trials evaluating treatment for patients with lenalidomide-refractory multiple myeloma.

Andrew Yee, MD, assistant professor of medicine, Harvard Medical School, hematologist/oncologist, Center for Multiple Myeloma, Massachusetts General Hospital, discusses trials evaluating treatment for patients with lenalidomide (Revlimid)-refractory multiple myeloma.

In the phase 3 OPTIMISMM trial, the overall response rate was 82.2% with the triplet combination of pomalidomide (Pomalyst), bortezomib (Velcade) and dexamethasone compared with 50.0% with bortezomib/dexamethasone alone in patients with relapsed/refractory multiple myeloma who received 1 to 3 prior lines of therapy, including a lenalidomide-containing regimen.

Additionally, the median progression-free survival was 11.2 months with the triplet versus 7.1 months with the doublet (HR, 0.61; 95% CI, 0.49-0.77; P <.0001).

The results of the OPTIMISMM trial have opened the door for other pomalidomide-containing triplet regimens in this space, concludes Yee.

Related Videos
Jorge E. Cortes, MD
R. Lor Randall, MD, FACS
Lisa A. Carey MD, ScM, FASCO
Gregory Vidal, MD, PhD
Joshua Hill, MD, MS
Gary K. Schwartz, MD
Maya Khalil, MD, assistant professor of medicine, Division of Hematology and Oncology, the University of Alabama at Birmingham (UAB), oncologist, O’Neal Comprehensive Cancer Center, UAB Medicine
Jeffery Zonder, MD
Jeffery Zonder, MD
Julie Renee Brahmer, MD
Related Content