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Opinion|Videos|January 23, 2025

Endocrine Sensitivity and the Prognostic and Clinical Implications

Author(s)Katherine Clifton, MD, Shipra Gandhi, MD

Dr. Gandhi and Dr. Clifton explore the prevalence and mechanisms of resistance to first-line endocrine therapy combined with CDK4/6 inhibitors in hormone receptor–positive/HER2-negative (HR+/HER2–) breast cancer.

Episodes in this series

EP. 1 Shifting Paradigms: Biomarker Testing and ESR1 Mutation Surveillance in HR+ HER2- Breast Cancer

EP. 1 Shifting Paradigms: Biomarker Testing and ESR1 Mutation Surveillance in HR+ HER2- Breast Cancer

EP. 2 Endocrine Sensitivity and the Prognostic and Clinical Implications

EP. 2 Endocrine Sensitivity and the Prognostic and Clinical Implications

EP. 3 Approved and Investigational SERDs in HR+/HER2– Breast Cancer

EP. 3 Approved and Investigational SERDs in HR+/HER2– Breast Cancer

EP. 4 Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials

EP. 4 Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials

EP. 5 Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

EP. 5 Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

EP. 6 Insights From SABCS 2024 and Future Directions in Breast Cancer

EP. 6 Insights From SABCS 2024 and Future Directions in Breast Cancer

Video content above is prompted by the following:

What proportion of patients with HR+/HER2– breast cancer experience resistance to first-line endocrine therapy plus CDK4/6 inhibitor?
What are some of the mechanisms of resistance that can emerge following endocrine therapy and CDK4/6 inhibitors in HR+/HER2– breast cancer?
How you think about endocrine resistance in the post-CDK4/6 setting? What signals—clinical, molecular, or otherwise—influence your treatment sequencing decisions?
How does treatment resistance after first-line treatment create challenges in selecting second-line therapies?

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