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Opinion|Videos|January 23, 2025

Approved and Investigational SERDs in HR+/HER2– Breast Cancer

Author(s)Katherine Clifton, MD, Shipra Gandhi, MD

Dr. Gandhi and Dr. Clifton discuss the evolving role of oral selective estrogen receptor degraders (SERDs) in the treatment paradigm for hormone receptor–positive/HER2-negative (HR+/HER2–) breast cancer, considering patient characteristics, clinical scenarios, and the landscape of approved and investigational agents, including elacestrant, imlunestrant, and camizestrant.

Episodes in this series

EP. 1 Shifting Paradigms: Biomarker Testing and ESR1 Mutation Surveillance in HR+ HER2- Breast Cancer

EP. 1 Shifting Paradigms: Biomarker Testing and ESR1 Mutation Surveillance in HR+ HER2- Breast Cancer

EP. 2 Endocrine Sensitivity and the Prognostic and Clinical Implications

EP. 2 Endocrine Sensitivity and the Prognostic and Clinical Implications

EP. 3 Approved and Investigational SERDs in HR+/HER2– Breast Cancer

EP. 3 Approved and Investigational SERDs in HR+/HER2– Breast Cancer

EP. 4 Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials

EP. 4 Imlunestrant Clinical Data: Insights From the EMBER and EMBER-3 Trials

EP. 5 Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

EP. 5 Translating Data With Oral SERDs to Practice: EMBER-3, SERENA-2, and Ongoing Trials

EP. 6 Insights From SABCS 2024 and Future Directions in Breast Cancer

EP. 6 Insights From SABCS 2024 and Future Directions in Breast Cancer

Video content above is prompted by the following:

With the emergence of oral SERDs, how do you see their role evolving in the treatment paradigm? What patient characteristics or clinical scenarios make you more likely to consider SERD therapy?
Please briefly highlight the landscape of oral SERDs, including approved and investigational agents in the pipeline:
- Elacestrant
- Imlunestrant
- Camizestrant
- Any others
What are your thoughts on implementing serial ESR1 mutation monitoring to guide earlier treatment changes? Do you see value in this proactive approach vs waiting for clinical/radiographic progression?
If novel agents show efficacy in both patients with ESR1-mutated disease and those with wild-type disease, do you anticipate ESR1 mutation status will remain as critical a biomarker for oral SERD use as we’re seeing with elacestrant?

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