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Commentary|Videos|October 7, 2025

Exploring Sigvotatug Vedotin–Based Combinations in Advanced NSCLC

Author(s)Julia Rotow, MD, Jyoti Malhotra, MD, MPH

Fact checked by: Chris Ryan

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the investigation of sigvotatug vedotin plus pembrolizumab in NSCLC.

Episodes in this series

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss unmet needs in second-line non–small cell lung cancer.

EP. 1 Treatment Approaches and Unmet Needs in Second-Line Advanced NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the rationale for evaluating IB6 as a target in non–small cell lung cancer.

EP. 2 Rationale for Evaluating IB6 as a Potential Therapeutic Target in NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the investigation of sigvotatug vedotin in nonsquamous NSCLC.

EP. 3 Evaluation of Sigvotatug Vedotin Monotherapy in Previously Treated, Nonsquamous NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the investigation of sigvotatug vedotin plus pembrolizumab in NSCLC.

EP. 4 Exploring Sigvotatug Vedotin–Based Combinations in Advanced NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss novel biomarkers under investigation in advanced NSCLC.

EP. 5 Novel Biomarkers to Watch in Advanced NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss unmet needs in advanced NSCLC.

EP. 6 Unmet Needs to Address in Advanced NSCLC

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