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Commentary|Videos|September 22, 2025

Treatment Approaches and Unmet Needs in Second-Line Advanced NSCLC

Author(s)Julia Rotow, MD, Jyoti Malhotra, MD, MPH

Fact checked by: Chris Ryan

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss unmet needs in second-line non–small cell lung cancer.

Episodes in this series

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss unmet needs in second-line non–small cell lung cancer.

EP. 1 Treatment Approaches and Unmet Needs in Second-Line Advanced NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the rationale for evaluating IB6 as a target in non–small cell lung cancer.

EP. 2 Rationale for Evaluating IB6 as a Potential Therapeutic Target in NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the investigation of sigvotatug vedotin in nonsquamous NSCLC.

EP. 3 Evaluation of Sigvotatug Vedotin Monotherapy in Previously Treated, Nonsquamous NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss the investigation of sigvotatug vedotin plus pembrolizumab in NSCLC.

EP. 4 Exploring Sigvotatug Vedotin–Based Combinations in Advanced NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss novel biomarkers under investigation in advanced NSCLC.

EP. 5 Novel Biomarkers to Watch in Advanced NSCLC

Julia Rotow, MD, and Jyoti Malhotra, MD, MPH, discuss unmet needs in advanced NSCLC.

EP. 6 Unmet Needs to Address in Advanced NSCLC

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