FDA Approval Insights: Tremelimumab Plus Durvalumab and Chemotherapy in NSCLC

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Dr Johnson discusses the FDA approval of tremelimumab plus durvalumab and chemotherapy in non–small cell lung cancer, key data from the POSEIDON trial, and the combination’s efficacy and tolerability in various patient populations.

Welcome to OncLive On Air®! I’m your host today, Ashling Wahner.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we had the pleasure of speaking with Melissa L. Johnson, MD, the director for lung cancer research at Sarah Cannon Research Institute at Tennessee Oncology and chair of the Cancer Committee at TriStar Centennial Medical Center in Nashville, Tennessee. Dr Johnson joined us to talk about the FDA approval of tremelimumab-actl (Imjudo) plus durvalumab (Imfinzi) and chemotherapy in non–small cell lung cancer (NSCLC).

On November 10, 2022, the FDA granted approval to the combination of tremelimumab, durvalumab, and platinum-based chemotherapy in adults with metastatic NSCLC without sensitizing EGFR mutations or ALK aberrations. This approval was supported by findings from the phase 3 POSEIDON trial (NCT03164616), in which the combination resulted in a 23% reduction in the risk of death over chemotherapy alone.

In our exclusive interview, Dr Johnson discussed the significance of this approval, shared key data from POSEIDON, and noted the combination’s efficacy and tolerability in various patient populations.

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