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Idalid Franco, MD, MPH, discusses the integration of immunotherapy, molecular biomarkers, and risk factors for recurrence into the endometrial cancer paradigm. 

Navigating the Intersection of Radiation Therapy and Immunotherapy in Endometrial Cancer

R. Lor Randall, MD, FACS, discusses the changing field of orthopedic oncology and gives his takeaways from the American Academy of Orthopedic Surgeons Meeting.

As Orthopedic Oncology Evolves, Caring for the Clinician Must Be a Priority  

Belumosudil elicited sustained responses and generated no new safety signals in patients with chronic graft-vs-host disease.

Belumosudil Produces Long-Term Responses Without New Safety Concerns in cGVHD

Itacitinib prophylaxis showed signals for reducing CRS and ICANS following treatment with axicabtagene ciloleucel in patients with B-cell lymphoma. 

Prophylactic Itacitinib May Safely Mitigate CRS Following Axi-Cel Administration in Lymphoma

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Sara Corvigno, MD, PhD, expands on an analysis that uncovered the CHIP variants that occurred at a higher frequency in patients with ovarian cancer post-chemotherapy.

Understanding Chemotherapy-Related Clonal Hematopoiesis in Ovarian Cancer

Rohan Garje, MD, highlights advances made in precision medicine approaches for the management of metastatic prostate cancer.

Garje Elucidates Biomarker-Driven Approaches Generating Excitement in Metastatic Prostate Cancer

Zeynep Eroglu, MD, discusses how findings from a phase 1/2 study of ceritinib and trametinib could help inform future research in melanoma. 

Toxicities Hinder Potential Efficacy of Ceritinib/Trametinib in Pretreated Advanced Melanoma

Kara N. Maxwell, MD, PhD, discusses the prevalence of germline mutations in racially diverse cohorts of patients with metastatic prostate cancer.  

Comparable Germline Variant Rates Seen Across Racial Groups in Metastatic Prostate Cancer

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Post-Conference Perspectives: Recent Advances in the Management of Chronic GvHD

Videos

Preet M. Chaudhary, MD, PhD and Noah Merin, MD, PhD discuss the chronic graft versus host disease treatment landscape, covering first- and second-line treatments and emergent trial data.

Preet M. Chaudhary, MD, PhD and Noah Merin, MD, PhD review how chronic GvHD is diagnosed, the different types of chronic GvHD, and key risk factors for the disease.

The Chronic GvHD Landscape:  Risk Factors and Diagnosis 

Expert clinicians discuss first-line treatment methodologies for chronic GvHD, with a focus on tailoring treatments to the patient. 


First-line Treatment for Patients with Chronic GvHD

Dr. Merin defines steroid refractory chronic GvHD, explains how to determine when patients become steroid-refractory and discusses treatment approach for this population. 


Defining and Managing Steroid Refractory Chronic GvHD

Dr. Chaudhary introduces data supporting the use of ruxolitinib as a first-line option in patients with steroid-refractory chronic GvHD. 


Role of Ruxolitinib in Steroid-Refractory Chronic GvHD

Dr. Merin describes the mechanisms of action of ruxolitinib, ibrutinib, and belumosudil and shares clinical pearls for community oncologists on methods for achieving response with these agents.

Understanding Mechanisms of Action: Ruxolitinib, Ibrutinib, and Belumosudil

A brief review of the key efficacy data for two treatment options, Ibrutinib and Belumosudil, in patients with chronic GvHD.

Key Efficacy Data of Ibrutinib and Belumosudil in Steroid-Refractory Chronic GvHD Patients

Discussion centered around real-world data following the approval of ruxolitinib as a treatment option for patients with chronic GvHD as well as discussing  treatment selection for patients with chronic GvHD, with special consideration for treatment sequencing.

Real World Data on the Use of Ruxolitinib and Treatment Selection in chronic GvHD

Dr. Chaudhary and Dr. Merin discuss potential areas for exploration and unmet needs in the chronic GvHD treatment landscape. 

Future Directions in Chronic GvHD

First-line Treatment for Patients with Chronic GvHD

EP: 1.The Chronic GvHD Landscape: Risk Factors and Diagnosis

EP: 2.First-line Treatment for Patients with Chronic GvHD

EP: 3.Defining and Managing Steroid Refractory Chronic GvHD

EP: 4.Role of Ruxolitinib in Steroid-Refractory Chronic GvHD

EP: 5.Understanding Mechanisms of Action: Ruxolitinib, Ibrutinib, and Belumosudil

EP: 6.Key Efficacy Data of Ibrutinib and Belumosudil in Steroid-Refractory Chronic GvHD Patients

EP: 7.Real World Data on the Use of Ruxolitinib and Treatment Selection in chronic GvHD

EP: 8.Future Directions in Chronic GvHD

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