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Opinion|Videos|May 12, 2026

Future Directions in Relapsed and Refractory Multiple Myeloma

Author(s)Ajay K. Nooka, MD, MPH, FACP, Noopur S. Raje, MD, Surbhi Sidana, MD

Episodes in this series

3 experts are featured in this series

EP. 1 Evolving Treatment Landscape in Relapsed and Refractory Multiple Myeloma

3 experts are featured in this series

EP. 2 Interpreting Emerging Data in Relapsed and Refractory Multiple Myeloma

3 experts are featured in this series

EP. 3 Key Factors Influencing Treatment Selection in Relapsed and Refractory Multiple Myeloma

3 experts are featured in this series

EP. 4 Treatment Sequencing Strategies in Relapsed and Refractory Multiple Myeloma

3 experts are featured in this series

EP. 5 Referral Timing and Access to Advanced Therapies in Multiple Myeloma

3 experts are featured in this series

EP. 6 Identifying Appropriate Candidates for Cellular Therapy in Multiple Myeloma

3 experts are featured in this series

EP. 7 Managing Toxicities and Supportive Care in Multiple Myeloma

3 experts are featured in this series

EP. 8 Balancing Clinical Trial and Real-World Evidence in Multiple Myeloma

3 experts are featured in this series

EP. 9 Choosing Among Treatment Options in Relapsed and Refractory Multiple Myeloma

3 experts are featured in this series

EP. 10 Functional High-Risk Versus Standard-Risk Multiple Myeloma

3 experts are featured in this series

EP. 11 Addressing Access Barriers in Relapsed and Refractory Multiple Myeloma

3 experts are featured in this series

EP. 12 Coordinating Care in Multiple Myeloma Across Practice Settings

3 experts are featured in this series

EP. 13 Sequencing Strategies After Progression in Multiple Myeloma

3 experts are featured in this series

EP. 14 Future Directions in Relapsed and Refractory Multiple Myeloma

In this segment, Dr. Ajay Nooka asks Dr. Noopur Raje to share her perspective on how emerging therapies and ongoing clinical trials are shaping the future of relapsed and refractory multiple myeloma. Dr. Raje discusses the rapid evolution of the treatment landscape, highlighting the continued development of novel agents and next-generation approaches that may further expand available options. She reflects on how ongoing research is informing not only treatment efficacy but also sequencing strategies and patient selection. The conversation also addresses key unanswered questions in multiple myeloma, including optimal sequencing of therapies, durability of response with newer modalities, and how best to individualize treatment approaches. Dr. Raje emphasizes the importance of continued clinical investigation to address these gaps and improve long-term outcomes. This segment provides a forward-looking perspective on the evolving management of multiple myeloma.

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