|Videos|September 1, 2020

HER2 Targeted Therapy for Treatment of NSCLC

Author(s)Joshua M. Bauml, MD, Perelman School of Medicine, Hossein Borghaei, DO, MS, Fox Chase Center at Temple Health, Balazs Halmos, MD, MS, Montefiore Einstein Center for Cancer Care

Detecting HER2 expression by IHC in lung cancer, the role of ADCs in targeting HER2 mutations, and the FDA breakthrough designation for trastuzumab deruxtecan are examined.

Data from the following clinical trials are discussed:

Trastuzumab deruxtecan (T-DXd; DS-8201) in patients with HER2-mutated metastatic non–small cell lung cancer: Interim results of DESTINY-Lung01. (Smit EF et al. 2020 ASCO annual meeting. Abstract 9504.)

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HER2 Targeted Therapy for Treatment of NSCLC

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Trastuzumab deruxtecan (T-DXd; DS-8201) in patients with HER2-mutated metastatic non–small cell lung cancer: Interim results of DESTINY-Lung01. (Smit EF et al. 2020 ASCO annual meeting. Abstract 9504.)

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