|Videos|September 1, 2020

EGFR Exon 20 Mutations in NSCLC

Author(s)Joshua M. Bauml, MD, Perelman School of Medicine, Hossein Borghaei, DO, MS, Fox Chase Center at Temple Health, Balazs Halmos, MD, MS, Montefiore Einstein Center for Cancer Care

Thoracic oncologists evaluate emerging data presented at the ASCO 2020 virtual meeting on agents for the treatment of EGFR exon 20 mutations.

Data from the following clinical trials are discussed:

ECOG-ACRIN 5162: A phase II study of osimertinib 160 mg in NSCLC with EGFR exon 20 insertions. (Piotrowska Z et al. 2020 ASCO annual meeting. Abstract 9513.)
Poziotinib shows activity and durability of responses in subgroups of previously treated EGFR exon 20 NSCLC patients. (Le X at al. 2020 ASCO annual meeting. Abstract 9514.)
Amivantamab (JNJ-61186372), an anti–EGFR-MET bispecific antibody, in patients with EGFR exon 20 insertion-mutated non–small cell lung cancer. (Park K et al. 2020 ASCO annual meeting. Abstract 9512.)

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EGFR Exon 20 Mutations in NSCLC

Data from the following clinical trials are discussed:

ECOG-ACRIN 5162: A phase II study of osimertinib 160 mg in NSCLC with EGFR exon 20 insertions. (Piotrowska Z et al. 2020 ASCO annual meeting. Abstract 9513.)

Poziotinib shows activity and durability of responses in subgroups of previously treated EGFR exon 20 NSCLC patients. (Le X at al. 2020 ASCO annual meeting. Abstract 9514.)

Amivantamab (JNJ-61186372), an anti–EGFR-MET bispecific antibody, in patients with EGFR exon 20 insertion-mutated non–small cell lung cancer. (Park K et al. 2020 ASCO annual meeting. Abstract 9512.)

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