Thoracic oncologists evaluate emerging data presented at the ASCO 2020 virtual meeting on agents for the treatment of EGFR exon 20 mutations.
Data from the following clinical trials are discussed:
ECOG-ACRIN 5162: A phase II study of osimertinib 160 mg in NSCLC with EGFR exon 20 insertions. (Piotrowska Z et al. 2020 ASCO annual meeting. Abstract 9513.)
Poziotinib shows activity and durability of responses in subgroups of previously treated EGFR exon 20 NSCLC patients. (Le X at al. 2020 ASCO annual meeting. Abstract 9514.)
Amivantamab (JNJ-61186372), an anti–EGFR-MET bispecific antibody, in patients with EGFR exon 20 insertion-mutated non–small cell lung cancer. (Park K et al. 2020 ASCO annual meeting. Abstract 9512.)