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Commentary|Videos|July 25, 2025

How the Mechanisms of KRAS(ON) Inhibitors Differ From KRAS(OFF) Inhibitors

Author(s)Martin Dietrich, MD, PhD, Mike J. Pishvaian, MD, PhD

Fact checked by: Chris Ryan

Mike J. Pishvaian, MD, PhD, and Martin Dietrich, MD, PhD, discuss how KRAS(ON) inhibitors differ in mechanism from KRAS(OFF) inhibitors.

Episodes in this series

Mike J. Pishvaian, MD, PhD, and Martin Dietrich, MD, PhD, detail the continued interest in RAS inhibition for pancreatic ductal adenocarcinoma.

EP. 1 Explaining the Continued Interest in RAS Inhibition for PDAC

Mike J. Pishvaian, MD, PhD, and Martin Dietrich, MD, PhD, discuss the prevalence of RAS mutations in pancreatic ductal adenocarcinoma.

EP. 2 The Prevalence of RAS Mutations in Metastatic PDAC

Mike J. Pishvaian, MD, PhD, and Martin Dietrich, MD, PhD, discuss the evolving role of KRAS G12C and pan-KRAS inhibitors in pancreatic cancer.

EP. 3 The Current and Evolving Role of KRAS G12C and Pan-KRAS Inhibitors in Metastatic PDAC

Mike J. Pishvaian, MD, PhD, and Martin Dietrich, MD, PhD, discuss how KRAS(ON) inhibitors differ in mechanism from KRAS(OFF) inhibitors.

EP. 4 How the Mechanisms of KRAS(ON) Inhibitors Differ From KRAS(OFF) Inhibitors

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