Ilson Delves Into the Development of Checkpoint Inhibition in Gastric/GEJ Cancers

Podcast

In Partnership With:

Dr. Ilson discusses treatment sequencing for patients with gastric and gastroesophageal junction cancer, the integration of immunotherapy into the frontline setting, and key ongoing studies in the field.

Welcome to OncLive On Air®! I’m your host today, Jessica Hergert.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, sponsored by Eli Lilly, we had the pleasure of speaking with David H. Ilson, MD, PhD, a medical oncologist at Memorial Sloan Kettering Cancer Center, to discuss current approaches to the treatment of patients with advanced or metastatic gastric cancer, gastroesophageal junction (GEJ) cancer, and esophageal adenocarcinoma following the approvals of 2 chemoimmunotherapy combinations in the frontline setting.

On May 5, 2021, the FDA approved pembrolizumab (Keytruda) plus trastuzumab (Herceptin), fluoropyrimidine- and platinum-containing chemotherapy for the frontline treatment of patients with locally advanced unresectable or metastatic HER2 positive gastric or GEJ adenocarcinoma. The regulatory decision was based on findings from a prespecified interim analysis of the first 264 patients enrolled to the KEYNOTE-811 trial (NCT03615326), which showed that the chemoimmunotherapy combination elicited an overall response rate (ORR) of 74% (95% CI, 66%-82%) vs 52% (95% CI, 43%-61%) with placebo (one-sided P <.0001).

Shortly thereafter, on April 16, 2021, the FDA approved nivolumab (Opdivo) plus select types of chemotherapy for the frontline treatment of patients with advanced or metastatic gastric cancer, GEJ cancer, and esophageal adenocarcinoma.

Data from the phase 3 CheckMate-649 trial (NCT02872116) showed that nivolumab plus leucovorin, 5-fluorouracil, and oxaliplatin (FOLFOX) or capecitabine and oxaliplatin resulted in a significant improvement in survival in treatment-naïve patients who had PD-L1–positive advanced gastric cancer, GEJ cancer, and esophageal adenocarcinoma vs chemotherapy alone.

In our exclusive interview, Ilson discussed treatment sequencing for patients with gastric/GEJ cancer, the integration of immunotherapy into the frontline setting, and key ongoing studies in the field.

Check back on Mondays and Thursdays for exclusive interviews with leading experts in the oncology field. For more updates in oncology, be sure to visit www.OncLive.com and sign up for our e-newsletters. 

OncLive is also on social media. On Twitter, follow us at @OncLive and @OncLiveSOSS. On Facebook, like us at OncLive and OncLive State of the Science Summit and follow our OncLive page on LinkedIn.

If you liked today’s episode of OncLive On Air®, please consider subscribing to our podcast on Apple Podcasts, Spotify, Google Podcasts, Amazon Music, and many of your other favorite podcast platforms,* so you get a notification every time a new episode is posted. While you are there, please take a moment to rate us!

Thanks again for listening to OncLive On Air®.

*OncLive On Air® is available on: Apple Podcasts, Google Podcasts, Spotify, Amazon Music, Audacy, CastBox, Deezer, iHeart, JioSaavn, Listen Notes, Player FM, Podcast Addict, Podchaser, RadioPublic, and TuneIn.

Related Videos
A panel of 5 experts on renal cell carcinoma
Chandler H. Park, MD, an expert on renal cell carcinoma
Video 6 - "Patient Case 2: A 62-Year-Old Woman with Metastatic Rectal Cancer"
Video 5 - "Adverse Events Associated With TAS-102 Plus Bevacizumab in CRC"
Michael J. Overman, MD
Saad Z. Usmani, MD, MBA, FACP, FASCO, chief, Myeloma Service, Memorial Sloan Kettering Cancer Center
Ilyas Sahin, assistant professor, Medicine, Department of Medicine, Division of Hematology & Oncology, University of Florida College of Medicine
Michael J. Overman, MD
Saad Z. Usmani, MD, MBA, FACP, FASCO, chief, Myeloma Service, Memorial Sloan Kettering Cancer Center
A panel of 5 experts on renal cell carcinoma