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Opinion|Videos|March 27, 2025

Integrating CAR T-Cell Therapy Into the Treatment Landscape for R/R DLBCL

Author(s)Rita Assi, MD , Girish Kunapareddy, MD

Experts discuss the role of chimeric antigen receptor T-cell therapy (CAR T) in the treatment landscape for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), how they sequence between bispecific antibodies and CAR T, the frequency and patient selection for CAR T in the second-line setting, and key takeaways from a recent oral presentation on real-world outcomes with axicabtagene ciloleucel (axi-cel) in the second-line setting from ASH 2024.

Episodes in this series

EP. 1 Integrating CAR T-Cell Therapy Into the Treatment Landscape for R/R DLBCL

EP. 1 Integrating CAR T-Cell Therapy Into the Treatment Landscape for R/R DLBCL

EP. 2 Bispecific Antibodies vs CAR T-Cell Therapy: Treatment Selection and Sequencing in Later-Line R/R DLBCL

EP. 2 Bispecific Antibodies vs CAR T-Cell Therapy: Treatment Selection and Sequencing in Later-Line R/R DLBCL

EP. 3 Selecting Candidates for CAR T-Cell Therapy in R/R DLBCL: Patient Characteristics, Eligibility, and Timing Considerations

EP. 3 Selecting Candidates for CAR T-Cell Therapy in R/R DLBCL: Patient Characteristics, Eligibility, and Timing Considerations

EP. 4 Expert Insights for Approaching Patient Counseling for CAR T-Cell Therapy in R/R DLBCL

EP. 4 Expert Insights for Approaching Patient Counseling for CAR T-Cell Therapy in R/R DLBCL

EP. 5 Practical Realities of CAR T-Cell Therapy for R/R DLBCL: Challenges and Lessons From the Community

EP. 5 Practical Realities of CAR T-Cell Therapy for R/R DLBCL: Challenges and Lessons From the Community

EP. 6 Optimal Strategies for Navigating Referral and Bridging Therapy for CAR T-Cell Therapy in R/R DLBCL Patients

EP. 6 Optimal Strategies for Navigating Referral and Bridging Therapy for CAR T-Cell Therapy in R/R DLBCL Patients

EP. 7 Safety Considerations for CAR T-Cell Therapy in R/R DLBCL

EP. 7 Safety Considerations for CAR T-Cell Therapy in R/R DLBCL

EP. 8 Outpatient CAR T-Cell Therapy for R/R DLBCL: Opportunities, Challenges, and Solutions

EP. 8 Outpatient CAR T-Cell Therapy for R/R DLBCL: Opportunities, Challenges, and Solutions

EP. 9 The Future of CAR T-Cell Therapy in R/R DLBCL: Closing Reflections and Key Takeaways

EP. 9 The Future of CAR T-Cell Therapy in R/R DLBCL: Closing Reflections and Key Takeaways

Video content above is prompted by the following:

Where does CAR T-cell therapy currently fall into your treatment landscape for R/R DLBCL ?
How are you sequencing between bispecific antibodies and CAR T in the treatment of DLBCL?
With the approval of 2 agents after first-line therapy, how frequently are you utilizing CAR T in the second-line setting, and for which patients?
There was a recent oral presentation about real-world outcomes with axi-cel in the second-line setting from ASH 2024. What are your key takeaways from it and has it impacted your decision-making?

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