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Opinion|Videos|April 17, 2025

Safety Considerations for CAR T-Cell Therapy in R/R DLBCL

Author(s)Rita Assi, MD , Girish Kunapareddy, MD

Experts discuss strategies for monitoring and managing cytokine release syndrome (CRS) and neurotoxicity, the influence of key takeaways from cohorts 4 and 6 of the ZUMA-1 trial on their practice, and how post- chimeric antigen receptor T-cell therapy (CAR T) follow-up care is managed between academic and community settings.

Episodes in this series

EP. 1 Integrating CAR T-Cell Therapy Into the Treatment Landscape for R/R DLBCL

EP. 1 Integrating CAR T-Cell Therapy Into the Treatment Landscape for R/R DLBCL

EP. 2 Bispecific Antibodies vs CAR T-Cell Therapy: Treatment Selection and Sequencing in Later-Line R/R DLBCL

EP. 2 Bispecific Antibodies vs CAR T-Cell Therapy: Treatment Selection and Sequencing in Later-Line R/R DLBCL

EP. 3 Selecting Candidates for CAR T-Cell Therapy in R/R DLBCL: Patient Characteristics, Eligibility, and Timing Considerations

EP. 3 Selecting Candidates for CAR T-Cell Therapy in R/R DLBCL: Patient Characteristics, Eligibility, and Timing Considerations

EP. 4 Expert Insights for Approaching Patient Counseling for CAR T-Cell Therapy in R/R DLBCL

EP. 4 Expert Insights for Approaching Patient Counseling for CAR T-Cell Therapy in R/R DLBCL

EP. 5 Practical Realities of CAR T-Cell Therapy for R/R DLBCL: Challenges and Lessons From the Community

EP. 5 Practical Realities of CAR T-Cell Therapy for R/R DLBCL: Challenges and Lessons From the Community

EP. 6 Optimal Strategies for Navigating Referral and Bridging Therapy for CAR T-Cell Therapy in R/R DLBCL Patients

EP. 6 Optimal Strategies for Navigating Referral and Bridging Therapy for CAR T-Cell Therapy in R/R DLBCL Patients

EP. 7 Safety Considerations for CAR T-Cell Therapy in R/R DLBCL

EP. 7 Safety Considerations for CAR T-Cell Therapy in R/R DLBCL

EP. 8 Outpatient CAR T-Cell Therapy for R/R DLBCL: Opportunities, Challenges, and Solutions

EP. 8 Outpatient CAR T-Cell Therapy for R/R DLBCL: Opportunities, Challenges, and Solutions

EP. 9 The Future of CAR T-Cell Therapy in R/R DLBCL: Closing Reflections and Key Takeaways

EP. 9 The Future of CAR T-Cell Therapy in R/R DLBCL: Closing Reflections and Key Takeaways

Video content above is prompted by the following:

What are your strategies for monitoring and managing CRS and neurotoxicity?
How did the key takeaways from cohorts 4 and 6 of the ZUMA-1 trial influence your practice?
How do you manage post–CAR T follow-up care between academic and community settings?

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