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Opinion|Videos|January 28, 2026

Interpreting Long-Term Data From monarchE and NATALEE

Author(s)Erica L. Mayer, MD, MPH, Kelly E. McCann, MD, PhD

Long-term follow-up from the monarchE and NATALEE trials continues to influence treatment decisions in HR-positive, HER2-negative early breast cancer.

Episodes in this series

2 experts are featured in this series.

EP. 1 Defining High-Risk HR-Positive Early Breast Cancer

2 experts are featured in this series.

EP. 2 Interpreting Long-Term Data From monarchE and NATALEE

Long-term follow-up from the monarchE and NATALEE trials continues to influence treatment decisions in HR-positive, HER2-negative early breast cancer. The faculty review updated invasive disease–free survival outcomes, the significance of overall survival benefit observed with abemaciclib, and the increasing maturity of ribociclib data. Particular attention is paid to node-negative and stage II populations, where confidence in benefit has evolved over time. The conversation explores how trial design, follow-up duration, and endpoint selection shape discussions with patients about absolute benefit and long-term outcomes. These insights help clinicians interpret emerging evidence and apply it appropriately in shared decision-making.

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