Medical Crossfire® — From Diagnostic Dilemmas to Potential Treatment Breakthroughs: Exploring Novel Targets for Extrapulmonary Neuroendocrine Carcinomas

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Episode Description

In this podcast, experts David S. Klimstra, MD; Danielle A. Hutchings, MD; Nancy M. Joseph, MD, PhD; and Jonathan Strosberg, MD; discuss how neuroendocrine neoplasms are defined, diagnosed, and treated and why distinguishing between tumor types is critical for prognosis and therapies.

Learning Objectives

Upon successful completion of this activity, you should be better prepared to:

• Apply current guideline-recommended criteria and diagnostic methods to accurately distinguish NECs from NETs
• Integrate molecular profiling and NGS into pathology

Acknowledgment of Educational Grant Support

This activity is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.

Faculty:

David S. Klimstra, MD

Louis J.M. Zinterhofer, MD Professor of Pathology
Yale University School of Medicine
New Haven, CT

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: Paige AI/Tempus; Ownership Interests: Paige AI/Tempus

Danielle A. Hutchings, MD

Assistant Professor
Pathology and Laboratory Medicine
Cedars-Sinai Medical Center
Los Angeles, CA

Danielle A. Hutchings, MD, has no relevant financial relationships with ineligible companies.

Nancy M. Joseph, MD, PhD

Professor, Department of Pathology
University of California, San Francisco
San Francisco, CA

Nancy M. Joseph, MD, PhD, has no relevant financial relationships with ineligible companies.

Jonathan Strosberg, MD

Professor, Department of Gastrointestinal Oncology
Moffitt Cancer Center
Tampa, FL

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: BI, Curium, Exelixis; Grant/Research Funding: BMS, Exelixis, ITM, Sanofi

Faculty, Staff, and Planners’ Disclosures

In accordance with ACCME Guidelines, PER^® has identified and resolved all conflicts of interest for faculty, staff, and planners prior to the start of this activity by using a multistep process.

The staff of Physicians’ Education Resource^®, LLC have no relevant financial relationships with ineligible companies.

This podcast, including the narration, was developed by PER^® editorial staff based on an online activity developed with these faculty. The narration was voiced by a PER staff member or by an AI tool.

To learn more about this topic, including information on diagnostic criteria, immunohistochemical interpretation, and clinical management of neuroendocrine tumors, go to https://www.gotoper.com/mc26epnces-activity.

Release Date

April 29, 2026

Expiration Date

April 29, 2027

Off-Label Disclosure and Disclaimer

This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER^® or any company that provided commercial support for this activity.