Molecular Testing in Stage 3 Melanoma

Video

Transcript:

Merrick I. Ross, MD: When making decisions about adjuvant therapy for patients with high-risk melanoma, it’s important to look at the data related to the use of biomarkers to identify specific patients for certain therapies. Currently, the only test that’s really relevant for these patients is BRAF testing, and it has to be an FDA-approved test.

In terms of other biomarkers, particularly for immunotherapy, if we’re looking at PD-L1 testing, it’s probably not a great biomarker. In the trials, there didn’t really seem to be a difference, in terms of the efficacy of immunotherapy, particularly for the checkpoint blockade, when using anti—PD-1 therapy. There didn’t seem to be a difference in the outcome, whether the patients were PD-L1–positive or PD-L1–negative.

BRAF is a very important marker. Patients who don’t have that mutation will not benefit from targeted therapy—specifically the approved combination of the BRAF inhibitor and the MEK inhibitor. So, for patients who are eligible for adjuvant therapy, BRAF testing is mandated, particularly if you’re going to consider the BRAF/MEK-targeted combination.

Transcript Edited for Clarity

Related Videos
Zeynep Eroglu, MD
Zeynep Eroglu, MD
Zeynep Eroglu, MD
Zeynep Eroglu, MD
Daniel Olson, MD
Vishal Patel, MD, FAAD, FACMS, associate professor, Dermatology, George Washington (GW) School of Medicine & Health Sciences
Omid Hamid, MD, professor, medicine, Cedars-Sinai; director, Clinical Research and Immunotherapy, director, Cutaneous Oncology and Melanoma, The Angeles Clinic and Research Institute
John M. Kirkwood, MD, Distinguished Service Professor of Medicine, Sandra and Thomas Usher Professor of Medicine, Dermatology & Translational Science, coleader, Melanoma and Skin Cancer Program, Division of Hematology/Oncology, the University of Pittsburgh
Daniel Olson, MD
Omid Hamid, MD