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Opinion|Videos|December 5, 2024

Navigating Toxicities: Trifluridine-Tipiracil Plus Bevacizumab

Author(s)Marwan G. Fakih, MD, City of Hope, Nilo Azad, MD

Panelists discuss the common toxicities associated with trifluridine-tipiracil plus bevacizumab in clinical practice, including their typical severity, and share their strategies for managing dose reductions and interruptions due to cytopenias when treating patients with this regimen.

Episodes in this series

EP. 1 Navigating mCRC: Treatment Options in the Third-Line Setting

EP. 1 Navigating mCRC: Treatment Options in the Third-Line Setting

$EP. 2 Nuances With Defining “Refractory” mCRC in the Third-Line Setting$

EP. 2 Nuances With Defining “Refractory” mCRC in the Third-Line Setting

EP. 3 Treatment Sequencing in mCRC: Balancing Expert Perspectives and Shared Decision-Making With Patients

EP. 3 Treatment Sequencing in mCRC: Balancing Expert Perspectives and Shared Decision-Making With Patients

EP. 4 Perspectives on the SUNLIGHT Trial: Study Design and Outcomes

EP. 4 Perspectives on the SUNLIGHT Trial: Study Design and Outcomes

EP. 5 Factoring in Health-Related Quality of Life Outcomes in mCRC Treatment Selection

EP. 5 Factoring in Health-Related Quality of Life Outcomes in mCRC Treatment Selection

EP. 6 Navigating Toxicities: Trifluridine-Tipiracil Plus Bevacizumab

EP. 6 Navigating Toxicities: Trifluridine-Tipiracil Plus Bevacizumab

EP. 7 Dosing Trifluridine-Tipiracil (TAS-102) Plus Bevacizumab Considerations: Hepatic or Renal Impairment

EP. 7 Dosing Trifluridine-Tipiracil (TAS-102) Plus Bevacizumab Considerations: Hepatic or Renal Impairment

EP. 8 Unmet Needs in Third-Line mCRC: Challenges and Opportunities

EP. 8 Unmet Needs in Third-Line mCRC: Challenges and Opportunities

Let’s further discuss these agents’ safety profiles and management strategies.… Dr Fakih, could you please discuss common toxicities that clinicians may see with trifluridine-tipiracil plus bevacizumab in their day-to-day practice?
1. What is the usual severity?
2. What is your treatment strategy in terms of dose reduction and/or interruptions due to cytopenias with trifluridine-tipiracil plus bevacizumab?

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