NCCN Guideline Updates and Clinical Judgment in Prostate Cancer Care

In this segment, Dr. Graham and Dr. Sokolova discuss how recent NCCN guideline updates have influenced clinical practice across biochemical recurrence and metastatic castration-sensitive prostate cancer. The conversation explores how expanding evidence has shaped guideline recommendations while also highlighting areas where individualized clinical judgment remains essential. Dr. Sokolova notes that guidelines provide a critical framework for evidence-based care but cannot account for all patient-specific factors encountered in routine practice. Both experts emphasize the importance of integrating guideline recommendations with real-world considerations such as patient comorbidities, preferences, and treatment tolerability. The discussion underscores that guidelines are intended to inform, rather than replace, clinician decision-making. Overall, this segment highlights how evolving NCCN guidance supports standardized care while allowing flexibility to tailor treatment strategies to individual patients with prostate cancer.