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Opinion|Videos|January 30, 2026

Treatment Suspension and Overall Survival in Biochemical Recurrence Prostate Cancer

Author(s)Laura Graham, MD , Alexandra Sokolova, MD

Explore the latest advancements in prostate cancer management, focusing on survival data, treatment strategies, and patient care considerations.

Episodes in this series

Experts featured in this series.

EP. 1 Evolving Overall Survival Trends in Prostate Cancer

Experts featured in this series.

EP. 2 Treatment Suspension and Overall Survival in Biochemical Recurrence Prostate Cancer

In this segment, Dr. Graham and Dr. Sokolova focus on the evolving evidence in biochemical recurrence (BCR) prostate cancer, with particular attention to longer-term follow-up data and the concept of treatment suspension. The discussion explores how recent studies have evaluated planned, protocol-defined treatment interruptions following an initial response, and how these strategies may influence overall survival and patient experience. Dr. Graham emphasizes the importance of carefully interpreting these findings within the context of study design, patient selection, and predefined criteria for monitoring and treatment re-initiation. Both experts highlight that treatment suspension is not intended as routine practice for all patients, but rather as a structured approach studied under controlled conditions. The segment underscores key clinical considerations, including balancing disease control with quality of life, minimizing cumulative toxicity, and counseling patients about expectations during off-treatment periods. Overall, this discussion provides insight into how emerging data are shaping thoughtful, individualized decision-making in high-risk BCR prostate cancer.

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