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Real-world data showed that atezolizumab provided a benefit and was safe in patients with platinum-ineligible mUC and high comorbidities/functional status.

First-Line Atezolizumab Is Suitable in Platinum-Based Chemotherapy Ineligible mUC 

Tanya Gupta, MD, highlights the utility of adjuvant CDK4/6 and PARP inhibitors in patients with HR-positive, HER2-negative breast cancer.

Adjuvant CDK4/6 Inhibitors Lay a Solid Treatment Foundation in HR+, HER2– Breast Cancer

Ocular adverse effects stemming from mirvetuximab soravtansine did not significantly affect HRQOL in FRα-positive platinum-resistant ovarian cancer.

Ocular AEs From Mirvetuximab Soravtansine Do Not Impact HRQOL in FRα+ Platinum-Resistant Ovarian Cancer

Treatment with abemaciclib plus hormonal therapy showed promise in LGSOC/EEC but not in HGSOC, and larger studies are needed to validate these findings.

Abemaciclib/Hormonal Therapy Combo Yields Clinical Activity in LGSOC/EEC

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Experts reflect on pivotal data, emerging agents, and highly-anticipated trends in gynecologic cancer care discussed during the 2025 SGO Annual Meeting. 

Emerging ADCs, Biomarker-Driven Treatments, and Diagnostic Advancements Take Center Stage at the SGO Annual Meeting

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Joshua Feinberg, MD, discusses the role of the Scout AI platform in aiding trial matching and treatment selection in oncology.

AI-Powered Scout Platform Could Enhance Oncology Decision-Making With Data- and Expert-Based Insights

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The FDA has approved TLX007-CDx as an imaging agent in select patients with prostate cancer.

FDA Approves PSMA PET Imaging Agent TLX007-CDx for Prostate Cancer

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ESMO 2020 News

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We are reporting from the 2020 ESMO Virtual Congress!

We are recapping some of the top news that are being presented during the conference—and in just a bit we’ll be speaking with Dr Robert Coleman to get his take on the biggest abstracts in gynecologic cancers, and also with Dr Shilpa Gupta on the latest in genitourinary cancers.

Welcome to OncLive News Network! I’m Gina Mauro.

In renal cell carcinoma, results of the phase 3 CheckMate-9ER trial showed that the combination of nivolumab and cabozantinib was found to double progression-free survival and objective response rates, and also significantly improve overall survival, compared with sunitinib, in patients with advanced disease who have not received prior treatment.

In basal cell carcinoma, the PD-1 antibody cemiplimab established encouraging clinical activity in patients with locally advanced disease who progress on or are intolerant to hedgehog inhibitors, regardless of PD-L1 expression, according to primary cohort results of a phase 2 trial presented during the meeting.

In an interim analysis of a subset of patients with intrahepatic cholangiocarcinoma harboring 

 fusions/rearrangements, the oral small molecule inhibitor futibatinib was shown to be efficacious and tolerable. Investigators recorded a 37.3% objective response rate in the analysis of 67 patients with at least 6 months of follow-up. One patient had complete response and 24 patients had partial response.

Findings from the phase 3 IPATunity trial showed that the combination of ipatasertib plus paclitaxel did not improve efficacy in patients with 

-altered hormone receptor–positive advanced breast cancer. However, follow-up for overall survival is ongoing.

A subgroup analysis from the phase 3 JAVELIN Bladder 100 trial demonstrated that frontline maintenance therapy with avelumab plus best supportive care provided an overall survival benefit compared with best supportive care alone across prespecified subgroups of patients whose disease had not progressed with frontline induction chemotherapy. Avelumab was approved by the FDA earlier in 2020 for this indication.

Two phase 2 trials in cervical cancer showcased activity with the PD-1 inhibitor balstilimab in patients with recurrent/metastatic disease. As a single agent, he response rate was 14% of all patients with the disease 19% in PD-L1–positive patients. For patients who received balstilimab plus the CTLA-4 inhibitor zalifrelimab, the ORRs were 22% and 27% in PD-L1–positive patients with recurrent/metastatic cervical cancer, respectively.

A first-in-human trial showed that the novel FAP-targeted 4-1BB agonist RO7122290 demonstrated an acceptable safety profile as a single agent and in combination with atezolizumab. Moreover, there were favorable pharmacokinetic and pharmacodynamic effects, and the preliminary antitumor activity supports further investigation in clinical trials.

For more coverage of the 2020 ESMO Virtual Congress, please be sure to visit 

That’s all for today. Tomorrow on OncLive News Network: On Location, we’ll speak with Dr Scott Tagawa to get perspectives on other studies being presentted in genitourinary cancers, and Dr Stephen Liu to get the latest ESMO abstracts in lung cancer.

Thank you for watching OncLive News Network! I’m Gina Mauro. 

Lenvatinib/Pembrolizumab Combo Shows Antitumor Activity in Previously Treated Advanced Solid Tumors

Frontline Ipatasertib/Abiraterone Regimen Shows Superior Radiographic PFS in PTEN-Loss mCRPC

Nivolumab/Chemo Improves PFS, Elicits Durable Responses in Gastric/GEJ Cancers

OncLive News Network On Location: ESMO 2020 Day 3

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