Biosimilars

Brain Cancer

Breast Cancer

Business Management

CAR T-cell Therapy

COVID-19

Chronic Lymphocytic Leukemia

Colorectal Cancer

Disparities in Cancer Care

Gastrointestinal Cancer

Genitourinary Cancers

Global Oncology

Gynecologic Oncology

Head & Neck Cancers

Hematologic Oncology

Immunotherapy in GU Cancers

Immunotherapy in Lung Cancer

Immunotherapy in Melanoma

Immuno-Oncology

Lung Cancer

Mantle Cell Lymphoma

Melanoma & Skin Cancer

Multiple Myeloma

Myeloproliferative Neoplasms

Neoadjuvant HER2+

Non-Hodgkin Lymphoma

Oncology Nursing News

Ovarian Cancer

Pediatric Oncology

Special Reports in Personalized Cancer Care

Precision Medicine in Oncology®

Prostate Cancer

Sarcomas/TGCT

Supportive Care

Urothelial Cancer

The use of talazoparib plus enzalutamide was manageable with dose modifications or standard supportive care treatment in patients with metastatic castration-resistant prostate cancer.

Talazoparib Plus Enzalutamide Has Manageble Toxicity With Dose Modifications, Supportive Care in mCRPC

Patients with nonmetastatic castration-resistant prostate cancer who received darolutamide were observed to have a longer time to treatment discontinuation and progression to metastatic castration-resistant disease than those who received enzalutamide or apalutamide.

Real-World Data Detail Potential Benefits of Darolutamide Over Other ARIs in nmCRPC

The addition of pembrolizumab to neoadjuvant platinum-based chemotherapy followed by resection and adjuvant pembrolizumab alone resulted in a significant improvement in event-free survival and pathological response for patients with early-stage non–small cell lung cancer.

Perioperative Pembrolizumab Shows Strong EFS, Response in Early-Stage NSCLC 

Zanidatamab generated responses in patients with HER2-amplified, locally advanced, unresectable or metastatic biliary tract cancer who were previously treated with gemcitabine.

Zanidatamab Elicits Responses in HER2-amplified Advanced Biliary Tract Cancer 

News

OncClub

All Oncology News

Pipeline Report

Media

Insights

Medical World News

OncChats

OncLive News Network®

OncLive TV

Peer Exchange

Podcasts

Rapid Readouts

The Talk

Conferences

Conference Coverage

Conference Listing

Events

Giants of Cancer Care

PER Events

Scientific Interchanges

State of the Science Summit / IPC

Webinars

Partners

Publications

OncologyLive

Oncology Fellows

Supplements And Featured Publications

All Publications

CME/CE

Resources

Interactive Tools

Learning Modules

Presentations

Subscribe

Print Subscription

eNewsletter

Articles

Silas Inman, Senior Vice President, Content, joined MJH Life Sciences™ in early 2011 as one of the company's first web editors. In this position, he built OncLive.com from a fledgling web platform to a leading source of oncology news for community oncologists via in-depth reporting of breaking news from major medical conferences and the launch of OncLive® TV. 

Throughout his tenure at MJH, Silas has been accountable for several organic launches of highly successful brands, including Targeted Oncology™ and NeurologyLive®, and for quickly transforming acquisitions into high-functioning business units. Prior to joining MJH, Silas, who attended Eastern Michigan University, was an EMT, frontend web developer, and social media/SEO expert. Follow him on Twitter 

OncLive serves as the connection to oncology, including groundbreaking cancer news and interviews with top oncologists in multimedia formats.

Advertise

About OncLive

Editorial Board

CancerNetwork.com

CGTlive.com

CureToday.com

OncNursingNews.com

TargetedOnc.com

Contact Us

Privacy

Terms & Conditions

Do Not Sell My Information

OncLive - Clinical Oncology News, Cancer Expert Insights

Facebook

Twitter

LinkedIn

Youtube

Spotlight

Join us in Chicago for Giants of Cancer Care®

OncLive® National Fellows Forum: Lung Cancer 2023

Specialty

1rem

primary

View

Videos

We are reporting from the 2020 ESMO Virtual Congress!

We are recapping some of the top news that are being presented during the conference—and in just a bit we’ll be speaking with Dr Robert Coleman to get his take on the biggest abstracts in gynecologic cancers, and also with Dr Shilpa Gupta on the latest in genitourinary cancers.

Welcome to OncLive News Network! I’m Gina Mauro.

In renal cell carcinoma, results of the phase 3 CheckMate-9ER trial showed that the combination of nivolumab and cabozantinib was found to double progression-free survival and objective response rates, and also significantly improve overall survival, compared with sunitinib, in patients with advanced disease who have not received prior treatment.

In basal cell carcinoma, the PD-1 antibody cemiplimab established encouraging clinical activity in patients with locally advanced disease who progress on or are intolerant to hedgehog inhibitors, regardless of PD-L1 expression, according to primary cohort results of a phase 2 trial presented during the meeting.

In an interim analysis of a subset of patients with intrahepatic cholangiocarcinoma harboring 

 fusions/rearrangements, the oral small molecule inhibitor futibatinib was shown to be efficacious and tolerable. Investigators recorded a 37.3% objective response rate in the analysis of 67 patients with at least 6 months of follow-up. One patient had complete response and 24 patients had partial response.

Findings from the phase 3 IPATunity trial showed that the combination of ipatasertib plus paclitaxel did not improve efficacy in patients with 

-altered hormone receptor–positive advanced breast cancer. However, follow-up for overall survival is ongoing.

A subgroup analysis from the phase 3 JAVELIN Bladder 100 trial demonstrated that frontline maintenance therapy with avelumab plus best supportive care provided an overall survival benefit compared with best supportive care alone across prespecified subgroups of patients whose disease had not progressed with frontline induction chemotherapy. Avelumab was approved by the FDA earlier in 2020 for this indication.

Two phase 2 trials in cervical cancer showcased activity with the PD-1 inhibitor balstilimab in patients with recurrent/metastatic disease. As a single agent, he response rate was 14% of all patients with the disease 19% in PD-L1–positive patients. For patients who received balstilimab plus the CTLA-4 inhibitor zalifrelimab, the ORRs were 22% and 27% in PD-L1–positive patients with recurrent/metastatic cervical cancer, respectively.

A first-in-human trial showed that the novel FAP-targeted 4-1BB agonist RO7122290 demonstrated an acceptable safety profile as a single agent and in combination with atezolizumab. Moreover, there were favorable pharmacokinetic and pharmacodynamic effects, and the preliminary antitumor activity supports further investigation in clinical trials.

For more coverage of the 2020 ESMO Virtual Congress, please be sure to visit 

That’s all for today. Tomorrow on OncLive News Network: On Location, we’ll speak with Dr Scott Tagawa to get perspectives on other studies being presentted in genitourinary cancers, and Dr Stephen Liu to get the latest ESMO abstracts in lung cancer.

Thank you for watching OncLive News Network! I’m Gina Mauro. 

Lenvatinib/Pembrolizumab Combo Shows Antitumor Activity in Previously Treated Advanced Solid Tumors

Frontline Ipatasertib/Abiraterone Regimen Shows Superior Radiographic PFS in PTEN-Loss mCRPC

OncLive News Network On Location ESMO 2020 Day 2

Latest Conference Coverage