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Opinion|Videos|August 28, 2024

Overview of CAR T-cell Therapy Options in R/R MM

Author(s)Robert Z. Orlowski, MD, PhD, Jonathan L. Kaufman, MD

The experts examine the available CAR T-cell therapy options for relapsed/refractory multiple myeloma.

Episodes in this series

2 KOLs are featured in this series.

EP. 1 Clinical Scenario I: 68-yr Old Man with Early Relapse MM

2 KOLs are featured in this series.

EP. 2 Clinical Insights on Next Treatment Approach Steps

2 KOLs are featured in this series.

EP. 3 Real Life Clinical Practice Use of Selinexor: Dosing Strategies, Supportive Care, and Strategies to Incorporate into Novel Selinexor-Based Regimens

2 KOLs are featured in this series.

EP. 4 Expert Perspectives: Navigating the Evolving Treatment Landscape in Early Relapse MM

2 KOLs are featured in this series.

EP. 5 Overview of CAR T-cell Therapy Options in R/R MM

2 KOLs are featured in this series.

EP. 6 Expert Perspectives: Selinexor Role in the Changing Treatment Landscape in MM and Key Takeaways

2 KOLs are featured in this series.

EP. 7 Patient Profile: 53-Year-Old Man with Heavily Pre-Treated MM including T-cell Directed Therapy

2 KOLs are featured in this series.

EP. 8 Clinical Insights on the Patient Presentation & Treatment Course

Robert Z. Orlowski, MD, PhD, and Jonathan Kaufman, MD

EP. 9 Challenges of Treatment Sequencing in Heavily Pre-Treated R/R MM: Expert Insights

Robert Z. Orlowski, MD, PhD, and Jonathan Kaufman, MD

EP. 10 Potential Novel Lab Monitoring & Key Takeaways for Heavily Pre-Treated R/R MM

Robert Z. Orlowski, MD, PhD, and Jonathan Kaufman, MD

EP. 11 Clinical Pearls & Unmet Needs in Early and Late Relapse R/R MM

Video content above is prompted by the following:

What current CAR T- cell therapy options are there for r/r MM? [EX1]
- Resource Link: CARVYKTI (cilta-cel) HCP website
- Reource Link: ABECMA (ide-cel) HCP website
What are some challenges with CAR T-cell therapy in r/r MM that you’ve experienced in your clinical practice? What are some potential resources and/or strategies to help support logistical challenges or early referral?
What is the role of bridging therapy prior to CAR T-cell therapy?
- How do you define “bridging therapy”?
- What is the potential role of Selinexor as bridging therapy, and how have you incoporated it in your practice?
  - Resource Link: Blood Cancer J 2024 Real-world impact of bridging therapy on ide-cel outcomes US Myeloma Immunotherapy Consortium
  - Resource Links: J Tansl Med 2023 XPO-1 inhibtior may enhance effect of BCMA CART extramedullary rr MM

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