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Opinion|Videos|May 30, 2025

Practical Recommendations for Community Oncologists Treating RRMM

Author(s)Aimaz Afrough, MD, Natalia Neparidze, MD

anelists discuss how the rapidly evolving treatment landscape for relapsed/refractory multiple myeloma requires personalized strategies, emphasizing the importance of patient-centric decision-making, effective therapy sequencing, and ongoing research to improve both efficacy and quality of life

Episodes in this series

EP. 1 Exploring the Treatment Options for RRMM

EP. 1 Exploring the Treatment Options for RRMM

EP. 2 Sequencing the Available T Cell– Engaging Therapies, and the Role of Bridging/Holding Therapy in RRMM

EP. 2 Sequencing the Available T Cell– Engaging Therapies, and the Role of Bridging/Holding Therapy in RRMM

EP. 3 Exploring T-Cell Fitness Strategies to Optimize Clinical Outcomes in RRMM

EP. 3 Exploring T-Cell Fitness Strategies to Optimize Clinical Outcomes in RRMM

EP. 4 Discussing the Treatment Options for RRMM Following Progression After BCMA CAR T Therapy

EP. 4 Discussing the Treatment Options for RRMM Following Progression After BCMA CAR T Therapy

EP. 5 Important Patient and Clinical Considerations When Choosing Therapy in RRMM Following CAR T Therapy

EP. 5 Important Patient and Clinical Considerations When Choosing Therapy in RRMM Following CAR T Therapy

EP. 6 Highlighting Selinexor in the RRMM Setting After CAR T Therapy

EP. 6 Highlighting Selinexor in the RRMM Setting After CAR T Therapy

EP. 7 Bispecific Antibodies for the Treatment of RRMM in the Post CAR T Setting

EP. 7 Bispecific Antibodies for the Treatment of RRMM in the Post CAR T Setting

EP. 8 Practical Recommendations for Community Oncologists Treating RRMM

EP. 8 Practical Recommendations for Community Oncologists Treating RRMM

Physician Summary: Closing Thoughts on the Discussion

Key Takeaway:

The treatment landscape for relapsed/refractory multiple myeloma (RRMM) is rapidly evolving with advancements in chimeric antigen receptor T-cell (CAR T) therapy, bispecific antibodies, and novel agents. It is essential to tailor treatment strategies based on disease progression, patient comorbidities, and immune fitness.
Ongoing research and clinical trials will continue to shape our approach, aiming for personalized treatment to improve both efficacy and quality of life.

Looking Ahead:

Patient-centric decision-making remains critical when selecting advanced therapies. As new therapies emerge, sequencing treatments effectively will be vital. The ability to choose the right therapy at the right time can significantly improve outcomes, and discussions like this are essential to optimize patient care.

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