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Opinion|Videos|January 12, 2026

Previewing the Phase 3 TERZO Trial of Duvelisib vs Gemcitabine or Bendamustine in Nodal TFH PTCL

Francine Foss, MD, and Matthew Lunning, DO, FACP, look ahead to the phase 3 TERZO trial of duvelisib in nodal TFH peripheral T-cell lymphoma.

Francine Foss, MD, and Matthew Lunning, DO, FACP, preview the design and objectives of the phase 3 TERZO trial (NCT06522737) comparing duvelisib (Copiktra) vs gemcitabine or bendamustine in patients with nodal TFH peripheral T-cell lymphoma. They discuss the rationale for the selected comparator arms and the importance of generating randomized data in this subtype. Foss and Lunning explain how results from TERZO could inform future treatment standards.

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