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Opinion|Videos|January 12, 2026

Previewing the Phase 3 TERZO Trial of Duvelisib vs Gemcitabine or Bendamustine in Nodal TFH PTCL

Author(s)Francine Foss, MD, Matthew Lunning, DO, FACP

Francine Foss, MD, and Matthew Lunning, DO, FACP, look ahead to the phase 3 TERZO trial of duvelisib in nodal TFH peripheral T-cell lymphoma.

Episodes in this series

EP. 1 Clinical Considerations for the Diagnosis and Management of Peripheral T-Cell Lymphoma

EP. 1 Clinical Considerations for the Diagnosis and Management of Peripheral T-Cell Lymphoma

EP. 2 Treatment Considerations for Newly Diagnosed vs Relapsed PTCL

EP. 2 Treatment Considerations for Newly Diagnosed vs Relapsed PTCL

EP. 3 PRIMO Trial: Data for Duvelisib in R/R PTCL

EP. 3 PRIMO Trial: Data for Duvelisib in R/R PTCL

EP. 4 Previewing the Phase 3 TERZO Trial of Duvelisib vs Gemcitabine or Bendamustine in Nodal TFH PTCL

EP. 4 Previewing the Phase 3 TERZO Trial of Duvelisib vs Gemcitabine or Bendamustine in Nodal TFH PTCL

EP. 5 Data for Duvelisib Plus Chidamide/CHOP in Newly Diagnosed AITL

EP. 5 Data for Duvelisib Plus Chidamide/CHOP in Newly Diagnosed AITL

EP. 6 Other Standout Data in PTCL From ASH 2025

EP. 6 Other Standout Data in PTCL From ASH 2025

Francine Foss, MD, and Matthew Lunning, DO, FACP, preview the design and objectives of the phase 3 TERZO trial (NCT06522737) comparing duvelisib (Copiktra) vs gemcitabine or bendamustine in patients with nodal TFH peripheral T-cell lymphoma. They discuss the rationale for the selected comparator arms and the importance of generating randomized data in this subtype. Foss and Lunning explain how results from TERZO could inform future treatment standards.

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