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Idalid Franco, MD, MPH, discusses the integration of immunotherapy, molecular biomarkers, and risk factors for recurrence into the endometrial cancer paradigm. 

Navigating the Intersection of Radiation Therapy and Immunotherapy in Endometrial Cancer

R. Lor Randall, MD, FACS, discusses the changing field of orthopedic oncology and gives his takeaways from the American Academy of Orthopedic Surgeons Meeting.

As Orthopedic Oncology Evolves, Caring for the Clinician Must Be a Priority  

Belumosudil elicited sustained responses and generated no new safety signals in patients with chronic graft-vs-host disease.

Belumosudil Produces Long-Term Responses Without New Safety Concerns in cGVHD

Itacitinib prophylaxis showed signals for reducing CRS and ICANS following treatment with axicabtagene ciloleucel in patients with B-cell lymphoma. 

Prophylactic Itacitinib May Safely Mitigate CRS Following Axi-Cel Administration in Lymphoma

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Vebreltinib has received approval from China’s NMPA in pretreated IDH-mutant, PTPRZ1-MET fusion–positive astrocytoma or glioblastoma.

Vebreltinib Receives NMPA Approval in China for MET Fusion+ Glioma

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CTX-009 plus paclitaxel has received FDA fast track designation for pretreated metastatic or locally advanced biliary tract cancer.

FDA Grants Fast Track Designation to CTX-009 Plus Paclitaxel for Pretreated Biliary Tract Cancer

A new drug application seeking the approval of toripalimab for the treatment of patients with nasopharyngeal carcinoma is under review in Hong Kong.

Toripalimab NDA Under Review in Hong Kong for Nasopharyngeal Carcinoma

HER2 gene expression is associated with prognostic and predictive value in patients with metastatic colorectal cancer.

Retrospective Data Show Association Between HER2 Expression and Survival Outcomes in mCRC

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Emerging First-Line Treatment Options for Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC)

Videos

Harry Yoon, MD and Nabil Saba, MD, FACP, discuss recent data on novel regimens for first-line treatment of advanced/metastatic ESCC, including the immunotherapy regimen tislelizumab.

Nabil Saba, MD, FACP and Harry Yoon, MD, briefly review the incidence of esophageal squamous cell carcinoma (ESCC), and describe how many patients present with unresectable locally advanced or metastatic disease in their clinical practice.

Trends in ESCC Incidence and Observations from Clinical Practice

Expert perspectives on the process of biomarker testing, including PD-L1 testing, for patients with unresectable locally advanced or metastatic ESCC.

Approaches to Biomarker Testing for ESCC

Drs Saba and Yoon share how a patient’s biomarker testing results typically affect prognosis and how they may influence subsequent treatment decision-making.

The Impact of Biomarker Results on Prognosis and Treatment Decision-Making

A focused discussion on the available first-line treatment options for advanced/metastatic ESCC.

First-Line Options for Advanced/Metastatic Disease

Drs Saba and Yoon share the factors they consider when choosing among available first-line regimens for ESCC, including clinical trial data and the patient’s PD-L1 expression status.

Insights on ESCC First-Line Treatment Selection

Dr Yoon introduces tislelizumab, an anti-PD-1 immunotherapy regimen being investigated as a first-line ESCC treatment option in combination with chemotherapy, and discusses recent conference data from the RATIONALE-306 trial.

RATIONALE-306 Data on Tislelizumab in ESCC

Drs Saba and Yoon reflect on how the potential FDA approval and availability of tislelizumab might change first-line ESCC treatment paradigms in the future.

The Potential Impact of Tislelizumab on First-Line ESCC Treatment

A review of other ongoing trials and emerging treatment regimens in the space and a summary of takeaways from trials on other squamous cell cancers that may also be applied to ESCC.

Other Emerging Regimens in ESCC and Lessons from Other Squamous Cell Cancers

Closing out their conversation, Drs Saba and Yoon share their hopes for the future of ESCC, including elucidating the molecular mechanisms behind immune evasion and treatment response to chemotherapy, radiation, and immunotherapy.

A Look Towards the Future of ESCC

RATIONALE-306 Data on Tislelizumab in ESCC

EP: 1.Trends in ESCC Incidence and Observations from Clinical Practice

EP: 2.Approaches to Biomarker Testing for ESCC

EP: 3.The Impact of Biomarker Results on Prognosis and Treatment Decision-Making

EP: 4.First-Line Options for Advanced/Metastatic Disease

EP: 5.Insights on ESCC First-Line Treatment Selection

EP: 6.RATIONALE-306 Data on Tislelizumab in ESCC

EP: 7.The Potential Impact of Tislelizumab on First-Line ESCC Treatment

EP: 8.Other Emerging Regimens in ESCC and Lessons from Other Squamous Cell Cancers

EP: 9.A Look Towards the Future of ESCC

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