Name: First-Line Options for Advanced/Metastatic Disease
Uploaded: 2023-01-16T20:09:16.209Z
Description: A focused discussion on the available first-line treatment options for advanced/metastatic ESCC.

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Emerging First-Line Treatment Options for Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC)

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Harry Yoon, MD and Nabil Saba, MD, FACP, discuss recent data on novel regimens for first-line treatment of advanced/metastatic ESCC, including the immunotherapy regimen tislelizumab.

Nabil Saba, MD, FACP and Harry Yoon, MD, briefly review the incidence of esophageal squamous cell carcinoma (ESCC), and describe how many patients present with unresectable locally advanced or metastatic disease in their clinical practice.

Trends in ESCC Incidence and Observations from Clinical Practice

Expert perspectives on the process of biomarker testing, including PD-L1 testing, for patients with unresectable locally advanced or metastatic ESCC.

Approaches to Biomarker Testing for ESCC

Drs Saba and Yoon share how a patient’s biomarker testing results typically affect prognosis and how they may influence subsequent treatment decision-making.

The Impact of Biomarker Results on Prognosis and Treatment Decision-Making

A focused discussion on the available first-line treatment options for advanced/metastatic ESCC.

First-Line Options for Advanced/Metastatic Disease

Drs Saba and Yoon share the factors they consider when choosing among available first-line regimens for ESCC, including clinical trial data and the patient’s PD-L1 expression status.

Insights on ESCC First-Line Treatment Selection

Dr Yoon introduces tislelizumab, an anti-PD-1 immunotherapy regimen being investigated as a first-line ESCC treatment option in combination with chemotherapy, and discusses recent conference data from the RATIONALE-306 trial.

RATIONALE-306 Data on Tislelizumab in ESCC

Drs Saba and Yoon reflect on how the potential FDA approval and availability of tislelizumab might change first-line ESCC treatment paradigms in the future.

The Potential Impact of Tislelizumab on First-Line ESCC Treatment

A review of other ongoing trials and emerging treatment regimens in the space and a summary of takeaways from trials on other squamous cell cancers that may also be applied to ESCC.

Other Emerging Regimens in ESCC and Lessons from Other Squamous Cell Cancers

Closing out their conversation, Drs Saba and Yoon share their hopes for the future of ESCC, including elucidating the molecular mechanisms behind immune evasion and treatment response to chemotherapy, radiation, and immunotherapy.

A Look Towards the Future of ESCC

First-Line Options for Advanced/Metastatic Disease

EP: 1.Trends in ESCC Incidence and Observations from Clinical Practice

EP: 2.Approaches to Biomarker Testing for ESCC

EP: 3.The Impact of Biomarker Results on Prognosis and Treatment Decision-Making

EP: 4.First-Line Options for Advanced/Metastatic Disease

EP: 5.Insights on ESCC First-Line Treatment Selection

EP: 6.RATIONALE-306 Data on Tislelizumab in ESCC

EP: 7.The Potential Impact of Tislelizumab on First-Line ESCC Treatment

EP: 8.Other Emerging Regimens in ESCC and Lessons from Other Squamous Cell Cancers

EP: 9.A Look Towards the Future of ESCC

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