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Opinion|Videos|May 11, 2026

Renal Cell Carcinoma: Practical Treatment Selection Across Risk Groups

Author(s)Elizabeth R. Plimack, MD, MS, FASCO, Sundhar Ramalingam, MD, Yasser Ged, MD

In this segment, Dr. Elizabeth Plimack leads a discussion with Dr. Sundhar Ramalingam and Dr. Yasser Ged on how clinicians approach treatment selection in renal cell carcinoma across different IMDC risk groups.

Episodes in this series

EP. 1 Renal Cell Carcinoma: Importance of First-Line Treatment Selection

EP. 1 Renal Cell Carcinoma: Importance of First-Line Treatment Selection

EP. 2 Renal Cell Carcinoma: Evolution of First-Line Clinical Trials

EP. 2 Renal Cell Carcinoma: Evolution of First-Line Clinical Trials

EP. 3 Renal Cell Carcinoma: Rationale for First-Line Combination Strategies

EP. 3 Renal Cell Carcinoma: Rationale for First-Line Combination Strategies

EP. 4 Renal Cell Carcinoma: Emerging Data in Non–Clear Cell Disease

EP. 4 Renal Cell Carcinoma: Emerging Data in Non–Clear Cell Disease

EP. 5 Renal Cell Carcinoma: Balancing Efficacy Endpoints in First-Line Treatment

EP. 5 Renal Cell Carcinoma: Balancing Efficacy Endpoints in First-Line Treatment

EP. 6 Renal Cell Carcinoma: Interpreting Survival and Response Outcomes

EP. 6 Renal Cell Carcinoma: Interpreting Survival and Response Outcomes

EP. 7 Renal Cell Carcinoma: Weighing PFS Versus Overall Survival

EP. 7 Renal Cell Carcinoma: Weighing PFS Versus Overall Survival

EP. 8 Renal Cell Carcinoma: Durable Responses and Long-Term Survival

EP. 8 Renal Cell Carcinoma: Durable Responses and Long-Term Survival

EP. 9 Renal Cell Carcinoma: Impact of First-Line Response on Sequencing

EP. 9 Renal Cell Carcinoma: Impact of First-Line Response on Sequencing

EP. 10 Renal Cell Carcinoma: Interpreting Cross-Trial Comparisons

EP. 10 Renal Cell Carcinoma: Interpreting Cross-Trial Comparisons

EP. 11 Renal Cell Carcinoma: Translating Trial Data to Real-World Practice

EP. 11 Renal Cell Carcinoma: Translating Trial Data to Real-World Practice

EP. 12 Renal Cell Carcinoma: Practical Treatment Selection Across Risk Groups

EP. 12 Renal Cell Carcinoma: Practical Treatment Selection Across Risk Groups

EP. 13 Renal Cell Carcinoma: Real-World Factors in First-Line Treatment Selection

EP. 13 Renal Cell Carcinoma: Real-World Factors in First-Line Treatment Selection

In this segment, Dr. Elizabeth Plimack leads a discussion with Dr. Sundhar Ramalingam and Dr. Yasser Ged on how clinicians approach treatment selection in renal cell carcinoma across different IMDC risk groups. The panel explores the challenge of navigating multiple approved IO-based combination regimens while maintaining efficiency in a busy clinical setting. Dr. Ramalingam and Dr. Ged discuss the importance of selecting therapies that are broadly applicable across patient populations, while also considering individual factors such as disease burden, comorbidities, and patient preferences. The conversation highlights the need to balance evidence-based decision-making with practical considerations, including ease of administration and toxicity management. This segment emphasizes strategies to streamline treatment selection without compromising the quality of care in renal cell carcinoma.

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