Video

Rapid Readouts: Results from two trials of TRK inhibitor, larotrectinib, in patients with TRK fusion-positive lung cancer

Alexander Drilon, MD presents data from the 2021 American Society of Clinical Oncology annual meeting from trials in adult and pediatric patients with tropomyosin receptor kinase (TRK) fusion-positive lung cancer treated with larotrectinib.

Alexander Drilon, MD, discusses data from the following presentation:

  • Long-term efficacy and safety of larotrectinib in patients with TRK fusion-positive lung cancer (Lin, 2021 ASCO Annual Meeting, abstract # 9109)
    • The objective of this presentation is to report updated results in patients with TRK fusion-positive lung cancers from the phase II adult/pediatric NAVIGATE basket trial (NCT02576431) and an adult phase 1 trial (NCT02122913) where patients were treated with larotrectinib.
    • Baseline characteristics
      • Central nervous system (CNS) metastases at baseline: 10 (50%) yes, 10 (50%) no
      • NTRK gene fusions (n = 20): NTRK1 80%; NTRK2 0%; NTRK3 20%
      • Tumor histology: 19 (95%) adenocarcinoma, 1 (5%) neuroendocrine carcinoma
    • Conclusions: efficacy
      • In all evaluable patients (n = 15), the overall response rate (ORR) was 73%, including 1 (7%) complete response, 10 (67%) partial response, 3 (20%) stable disease, and 1 (7%) progressive disease; responses were durable with a median progression-free survival (PFS) of 35.4 months and median duration of response of 33.9 months. Median overall survival was 40.7 months.
      • In patients with CNS metastases (n = 10), the ORR was 63%, including 5 (52%) partial response, 2 (25%) stable disease, and 1 (13%) progressive disease.
    • Conclusions: safety
      • Treatment-related adverse events (TRAEs) were predominantly grade 1 and 2.
      • TRAEs were reported by 16 patients (80%); 2 patients (10%) experienced grade 3 TRAE (myalgia, hypersensitivity, and weight increase).
      • Two patients (10%) required dose reduction due to AEs: grade 2 ALT and grade 2 AST increase in 1 patient and grade 2 neutrophil count decrease in the other patient; there were no treatment discontinuations due to AEs.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity
Related Content