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Opinion|Videos|December 3, 2025

Safety Considerations for BRAF Inhibition in CNS Malignancies

Author(s)Patrick Y. Wen, MD, Karisa C. Schreck, MD, PhD

Patrick Y. Wen, MD, and Karisa C. Schreck, MD, PhD, discuss the safety profile and management of toxicities associated with BRAF inhibitors in central nervous system tumors.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Treatment Standards in Primary CNS Malignancies

2 experts are featured in this series.

EP. 2 The Role of BRAF Inhibition in CNS Malignancies

2 experts are featured in this series.

EP. 3 Detailing the Exploration of Plixorafenib in CNS Malignancies

2 experts are featured in this series.

EP. 4 Safety Considerations for BRAF Inhibition in CNS Malignancies

2 experts are featured in this series.

EP. 5 The FORTE Trial: Data for Plixorafenib in BRAF V600+ CNS Tumors

2 experts are featured in this series.

EP. 6 Ongoing Research in Primary CNS Malignancies

2 experts are featured in this series.

EP. 7 Future Research Directions in Primary CNS Tumors

Patrick Y. Wen, MD, and Karisa C. Schreck, MD, PhD, discuss the safety profile and management of toxicities associated with BRAF inhibitors in central nervous system tumors.

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