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Opinion|Videos|March 16, 2026

Sequencing in EGFR+ NSCLC: How MET Amplifications and Other Factors Guide Decisions

Author(s)Samuel Rosner, MD, Laura Alder, MD

Experts featured in this series.

Samuel Rosner, MD, and Laura Alder, MD, discuss how MET status and other factors can help inform sequencing decisions in EGFR-mutated NSCLC.

Samuel Rosner, MD, and Laura Alder, MD, discuss how resistance mechanisms shape treatment sequencing strategies in EGFR-mutated non–small cell lung cancer. Rosner reviews common drivers of disease progression, including MET amplification and other molecular alterations that may emerge following EGFR-targeted therapy. Alder explains how repeat molecular testing and evolving tumor biology can guide subsequent treatment decisions and help optimize therapeutic sequencing.

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