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Commentary|Articles|October 24, 2025

The Challenge of Combination Therapy in the Frontline Setting

Episodes in this series

EP. 1 Precision Medicine Correlates with Reduced Cancer Mortality Rates in EGFRm mNSCLC: Data from 1994-2020

EP. 1 Precision Medicine Correlates with Reduced Cancer Mortality Rates in EGFRm mNSCLC: Data from 1994-2020

EP. 2 Biomarker Testing: Utilization Gains Tempered by Ongoing Implementation Challenges

EP. 2 Biomarker Testing: Utilization Gains Tempered by Ongoing Implementation Challenges

EP. 3 Evaluating the Frontline Treatment Options in EGFRm mNSCLC

EP. 3 Evaluating the Frontline Treatment Options in EGFRm mNSCLC

EP. 4 FLAURA-2 Overall Survival Data and Identifying Patient Populations Benefitting from Upfront Combination Therapy

EP. 4 FLAURA-2 Overall Survival Data and Identifying Patient Populations Benefitting from Upfront Combination Therapy

EP. 5 Reviewing the Combination Regimens and Assessing Risk-Benefit

EP. 5 Reviewing the Combination Regimens and Assessing Risk-Benefit

EP. 6 AI and Computational Models Could Predict Responses and Individualize Future Treatment Decisions

EP. 6 AI and Computational Models Could Predict Responses and Individualize Future Treatment Decisions

EP. 7 The Challenge of Combination Therapy in the Frontline Setting

EP. 7 The Challenge of Combination Therapy in the Frontline Setting

EP. 8 Redefining Tolerability Amid Treatment Discontinuation

EP. 8 Redefining Tolerability Amid Treatment Discontinuation

EP. 9 The Impact of the COCOON regimen on Amivantamab Toxicities

EP. 9 The Impact of the COCOON regimen on Amivantamab Toxicities

EP. 10 Testing New Dosing Strategies to Improve Treatment Tolerability

EP. 10 Testing New Dosing Strategies to Improve Treatment Tolerability

EP. 11 Treatment Resistance Patterns Can Inform Therapy Sequencing and the Need to Rebiopsy

EP. 11 Treatment Resistance Patterns Can Inform Therapy Sequencing and the Need to Rebiopsy

EP. 12 Evaluating the Benefit of Continuing the EGFR Targeted TKI in 2L Treatment

EP. 12 Evaluating the Benefit of Continuing the EGFR Targeted TKI in 2L Treatment

EP. 13 The Role of Tumor Agnostic Therapies in the Treatment of EGFRm mNSCLC

EP. 13 The Role of Tumor Agnostic Therapies in the Treatment of EGFRm mNSCLC

EP. 14 The Need to Identify Better Predictive Biomarkers for Treatment Response

EP. 14 The Need to Identify Better Predictive Biomarkers for Treatment Response

EP. 15 Looking Ahead to Future Treatment Options for EGFRm mNSCLC

EP. 15 Looking Ahead to Future Treatment Options for EGFRm mNSCLC

EP. 16 HARMONi and Ivonescimab Data from WCLC

EP. 16 HARMONi and Ivonescimab Data from WCLC

EP. 17 Wrap Up From WCLC 2025

EP. 17 Wrap Up From WCLC 2025

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